A0A7K5N375 · A0A7K5N375_CHRMC
- Proteinornithine decarboxylase
- GeneOdc1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids460 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.
Catalytic activity
- H+ + L-ornithine = CO2 + putrescine
Cofactor
Pathway
Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 360 | Proton donor | ||||
Sequence: C |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ornithine decarboxylase activity | |
Biological Process | putrescine biosynthetic process from ornithine |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameornithine decarboxylase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Charadriiformes > Laridae > Chroicocephalus
Accessions
- Primary accessionA0A7K5N375
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Modified residue | 69 | N6-(pyridoxal phosphate)lysine | ||||
Sequence: K |
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 45-281 | Orn/DAP/Arg decarboxylase 2 N-terminal | ||||
Sequence: LGDIVKKHMRWHKALPRVTPFYAVKCNDSKAVVKTLAVLGAGFDCASKTEIQLVQSIGVSPERIIYANPCKQVSQIKHAASSGVQMMTFDSEVELMKVARAHPKAKLVLRITTDDSKAVCRLSVKFGATLKTSRLLLERAKELDLAIIGVSFHVGSGCTDPETFVQAISDARCVFDMGAELGFNMYLLDIGGGFPGSEDVKLKFEEITSVINPALDKYFPSDSGINIIAEPGRYYVA | ||||||
Domain | 282-387 | Orn/DAP/Arg decarboxylase 2 C-terminal | ||||
Sequence: SAFTLAVNIIAKKIVLKEQTGSDDEDDANDKTLMYYVNDGVYGSFNCILYDHAHVKPVLQKRPKPDDSCYSCSIWGPTCDGLDRIVERFNMPELQVGDWILFENMG |
Sequence similarities
Belongs to the Orn/Lys/Arg decarboxylase class-II family.
Family and domain databases
Sequence
- Sequence statusFragment
- Length460
- Mass (Da)50,815
- Last updated2021-04-07 v1
- ChecksumB03DE84ED5A5E448
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: M | ||||||
Non-terminal residue | 460 | |||||
Sequence: V |