A0A7K5N375 · A0A7K5N375_CHRMC

Function

function

Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

pyridoxal 5'-phosphate (UniProtKB | Rhea| CHEBI:597326 )

Pathway

Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site360Proton donor

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionornithine decarboxylase activity
Biological Processputrescine biosynthetic process from ornithine

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ornithine decarboxylase
  • EC number

Gene names

    • Name
      Odc1
    • ORF names
      CHRMAC_R13665

Organism names

Accessions

  • Primary accession
    A0A7K5N375

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue69N6-(pyridoxal phosphate)lysine

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain45-281Orn/DAP/Arg decarboxylase 2 N-terminal
Domain282-387Orn/DAP/Arg decarboxylase 2 C-terminal

Sequence similarities

Belongs to the Orn/Lys/Arg decarboxylase class-II family.

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    460
  • Mass (Da)
    50,815
  • Last updated
    2021-04-07 v1
  • Checksum
    B03DE84ED5A5E448
MSNFSSEEFEFTFLDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDIVKKHMRWHKALPRVTPFYAVKCNDSKAVVKTLAVLGAGFDCASKTEIQLVQSIGVSPERIIYANPCKQVSQIKHAASSGVQMMTFDSEVELMKVARAHPKAKLVLRITTDDSKAVCRLSVKFGATLKTSRLLLERAKELDLAIIGVSFHVGSGCTDPETFVQAISDARCVFDMGAELGFNMYLLDIGGGFPGSEDVKLKFEEITSVINPALDKYFPSDSGINIIAEPGRYYVASAFTLAVNIIAKKIVLKEQTGSDDEDDANDKTLMYYVNDGVYGSFNCILYDHAHVKPVLQKRPKPDDSCYSCSIWGPTCDGLDRIVERFNMPELQVGDWILFENMGAYTVAAASTFNGFQRPTIHYVMSRPAWQLMQQIKEQGFLAEVEEQDVASLPLSCAWESGIEYPATCASASINV

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue460

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
VYZF01000077
EMBL· GenBank· DDBJ
NWT36893.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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