A0A7K5B0K1 · A0A7K5B0K1_9FURN
- Proteinadenylate cyclase
- GeneAdcy2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1102 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
Catalytic activity
- ATP = 3',5'-cyclic AMP + diphosphate
Cofactor
Protein has several cofactor binding sites:
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )
Note: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 301 | Mg2+ 1 (UniProtKB | ChEBI); catalytic | ||||
Sequence: D | ||||||
Binding site | 301 | Mg2+ 2 (UniProtKB | ChEBI); catalytic | ||||
Sequence: D | ||||||
Binding site | 301-306 | ATP (UniProtKB | ChEBI) | ||||
Sequence: DIVGFT | ||||||
Binding site | 302 | Mg2+ 2 (UniProtKB | ChEBI); catalytic | ||||
Sequence: I | ||||||
Binding site | 343-345 | ATP (UniProtKB | ChEBI) | ||||
Sequence: LGD | ||||||
Binding site | 345 | Mg2+ 1 (UniProtKB | ChEBI); catalytic | ||||
Sequence: D | ||||||
Binding site | 345 | Mg2+ 2 (UniProtKB | ChEBI); catalytic | ||||
Sequence: D | ||||||
Binding site | 389 | ATP (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 950 | ATP (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 1030-1032 | ATP (UniProtKB | ChEBI) | ||||
Sequence: DIW | ||||||
Binding site | 1037-1041 | ATP (UniProtKB | ChEBI) | ||||
Sequence: NVASR | ||||||
Binding site | 1077 | ATP (UniProtKB | ChEBI) | ||||
Sequence: K |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | adenylate cyclase activity | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Biological Process | cAMP biosynthetic process | |
Biological Process | intracellular signal transduction |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameadenylate cyclase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Passeriformes > Furnariidae > Furnarius
Accessions
- Primary accessionA0A7K5B0K1
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 52-76 | Helical | ||||
Sequence: LIVFLLLIVMGACLALLAVFFASGL | ||||||
Transmembrane | 82-102 | Helical | ||||
Sequence: VAFLITVPTALAIFFAIFILV | ||||||
Transmembrane | 114-137 | Helical | ||||
Sequence: IFSLVVWVCLVAMGYLFMCFGGII | ||||||
Transmembrane | 143-159 | Helical | ||||
Sequence: VSFFLFIIFVVYTMLPF | ||||||
Transmembrane | 166-187 | Helical | ||||
Sequence: VASVLTSASHTIVLSVCLSGTA | ||||||
Transmembrane | 193-213 | Helical | ||||
Sequence: LVWQILANVIIFICGNLAGAY | ||||||
Transmembrane | 606-627 | Helical | ||||
Sequence: FKYYVTCACLIFFCIFVVQILV | ||||||
Transmembrane | 633-658 | Helical | ||||
Sequence: ILGISFGAAFLLLSFILFVCFAGQLL | ||||||
Transmembrane | 686-707 | Helical | ||||
Sequence: ITLTLTTTAIILTMAIFNMFFL | ||||||
Transmembrane | 742-763 | Helical | ||||
Sequence: FLPYFIYSCILGLISCSVFLRI | ||||||
Transmembrane | 770-788 | Helical | ||||
Sequence: VIMLIALVGYNVILLHTHG | ||||||
Transmembrane | 813-831 | Helical | ||||
Sequence: LKTMGSISLFIFFITLLVL |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 296-423 | Guanylate cyclase | ||||
Sequence: SILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLQNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHME | ||||||
Domain | 898-1043 | Guanylate cyclase | ||||
Sequence: CVMFASVPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSATPNQEQCQEPERQYMHIGTMVEFAFALVAKLDVINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMD |
Sequence similarities
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length1,102
- Mass (Da)125,071
- Last updated2021-04-07 v1
- Checksum87034598A0FC2DE5
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: M | ||||||
Non-terminal residue | 1102 | |||||
Sequence: S |
Keywords
- Technical term