A0A7K2TM37 · A0A7K2TM37_9ACTN
- ProteinGlutathione hydrolase proenzyme
- Geneggt
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids617 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate
Pathway
Sulfur metabolism; glutathione metabolism.
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | glutathione hydrolase activity | |
Molecular Function | leukotriene C4 gamma-glutamyl transferase activity | |
Biological Process | glutathione biosynthetic process | |
Biological Process | glutathione catabolic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGlutathione hydrolase proenzyme
- EC number
- Cleaved into 2 chains
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Kitasatosporales > Streptomycetaceae > Streptomyces
Accessions
- Primary accessionA0A7K2TM37
Proteomes
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-29 | |||||
Sequence: MRRPVLRNVTLLAAAAVVASVGAAAPPTA | ||||||
Chain | PRO_5039027910 | 30-617 | Glutathione hydrolase proenzyme | |||
Sequence: ARTGPAPIPAPAPAPAPARAATPAKTPVAVGHGGAVASVDADASAAGIEVLRNGGNAVDAAVATAAALGVTEPYSSGIGGGGYFVHYDARTRTVRTIDGRETAPLSADASLFTENGAPLPFDTAVTSGLAVGTPGTPATWQAALDRWGTRSLASVLKPAERLAQRGFTVDETFRSQTAANEERFRHFPDTARLFLPKGAPPAVGSTFRNPDLARTYRQLGREGVDAVYRGAIGKDIVATVNKPPTDPRSGWTARPGDLSAKDLKAYRAKVQAPTRTSYRGLGIYSIAPSSSGGTTVGEALNILERTDLARAGETRYLHRFIEASRVAFADRGRWVGDPGFEDVPVRELLSQRYADSRGCLIKDDAVLTSPLAPGDPRHPAPCARGGAAAPTTYEGENTTHLTVADRWGNVVSYTLTIEQTGGSGITVPGRGFLLNNELTDFSFAPASPAVHDPNLPGPGKRPRSSLAPTIVLNADDRPVLAVGSPGGATIITTVLQTLTGVLDRGLPLVDAIAAPRASQRNAARTELEPGLYDSAVRGRLEAIGHSFKLNPEIGAATGVQRLPDGRWLAAAEKVRRGGGSAMVVRPQR |
Post-translational modification
Cleaved by autocatalysis into a large and a small subunit.
Keywords
- PTM
Interaction
Subunit
This enzyme consists of two polypeptide chains, which are synthesized in precursor form from a single polypeptide.
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 28-55 | Disordered | ||||
Sequence: TAARTGPAPIPAPAPAPAPARAATPAKT | ||||||
Compositional bias | 31-49 | Pro residues | ||||
Sequence: RTGPAPIPAPAPAPAPARA |
Sequence similarities
Belongs to the gamma-glutamyltransferase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length617
- Mass (Da)64,169
- Last updated2021-04-07 v1
- Checksum08B98404B159F742
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 31-49 | Pro residues | ||||
Sequence: RTGPAPIPAPAPAPAPARA |
Keywords
- Technical term