A0A7J2IDN7 · A0A7J2IDN7_UNCAA

  • Protein
    Aspartate carbamoyltransferase
  • Gene
    pyrB
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the condensation of carbamoyl phosphate and aspartate to form carbamoyl aspartate and inorganic phosphate, the committed step in the de novo pyrimidine nucleotide biosynthesis pathway.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site57carbamoyl phosphate (UniProtKB | ChEBI)
Binding site58carbamoyl phosphate (UniProtKB | ChEBI)
Binding site86L-aspartate (UniProtKB | ChEBI)
Binding site107carbamoyl phosphate (UniProtKB | ChEBI)
Binding site135carbamoyl phosphate (UniProtKB | ChEBI)
Binding site138carbamoyl phosphate (UniProtKB | ChEBI)
Binding site168L-aspartate (UniProtKB | ChEBI)
Binding site227L-aspartate (UniProtKB | ChEBI)
Binding site266carbamoyl phosphate (UniProtKB | ChEBI)
Binding site267carbamoyl phosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionamino acid binding
Molecular Functionaspartate carbamoyltransferase activity
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological Process'de novo' UMP biosynthetic process
Biological Processamino acid metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Aspartate carbamoyltransferase
  • EC number
  • Alternative names
    • Aspartate transcarbamylase
      (ATCase
      )

Gene names

    • Name
      pyrB
    • ORF names
      ENG12_02780

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • HyVt-188
  • Taxonomic lineage
    Archaea > Candidatus Altarchaeota > Candidatus Altiarchaeia > Candidatus Altarchaeales

Accessions

  • Primary accession
    A0A7J2IDN7

Proteomes

Interaction

Subunit

Heterooligomer of catalytic and regulatory chains.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain6-147Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Domain154-301Aspartate/ornithine carbamoyltransferase Asp/Orn-binding

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    308
  • Mass (Da)
    34,465
  • Last updated
    2021-04-07 v1
  • Checksum
    65289EFA33ACD65A
MRWTKKHIISINDFSRDEIDFVLEKSGILEKKLGSSSTSSLMNGKILANLFFEPSTRTRMSFEAAMKRLGGITIGFDHPGISSEVKGETIADTVRIVSGYADLIVIRHPIEGSARLASEYSDVPVINGGDGSNQHPTQTLLDLYTIKKEFKSIDGLDICIVGDLKYGRTVHSLASALGNYDVKIRFISPQELRAPRQIVKSLSDRGIEVKETTKLNLKNSDVIYVTRIQKERFPDPQEYERVKGAFVLNLNSLEGIRENAIIMHPLPRVSEISPDIDATKHARYFEQAKNGIPVRMALLCLVCGIKFW

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DQZU01000100
EMBL· GenBank· DDBJ
HDH41316.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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