A0A7J0AK13 · A0A7J0AK13_9BACT

Function

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Probably binds two magnesium or manganese ions per subunit.
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Features

Showing features for binding site, active site, site.

125020406080100120140160180200220240
TypeIDPosition(s)Description
Binding site7Mg2+ 1 (UniProtKB | ChEBI)
Binding site35Mg2+ 1 (UniProtKB | ChEBI)
Active site105
Active site144Proton donor/acceptor
Binding site144Mg2+ 1 (UniProtKB | ChEBI)
Binding site146Mg2+ 1 (UniProtKB | ChEBI)
Site146Transition state stabilizer
Site216Important for catalytic activity
Binding site241Mg2+ 1 (UniProtKB | ChEBI)
Active site242Proton acceptor
Binding site242Mg2+ 1 (UniProtKB | ChEBI)
Site242Interaction with DNA substrate

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular FunctionDNA binding
Molecular FunctionDNA-(apurinic or apyrimidinic site) endonuclease activity
Molecular Functiondouble-stranded DNA 3'-5' DNA exonuclease activity
Molecular Functionendonuclease activity
Molecular Functionmetal ion binding
Molecular Functionphosphoric diester hydrolase activity
Biological Processbase-excision repair

Keywords

Names & Taxonomy

Protein names

  • Submitted names
    • Exodeoxyribonuclease
      (EC:3.1.11.2
      )

Gene names

    • Name
      exoA
    • ORF names
      IMSAGC008_01233

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • IMSAGC_008
  • Taxonomic lineage
    Bacteria > Bacteroidota > Bacteroidia > Bacteroidales > Muribaculaceae

Accessions

  • Primary accession
    A0A7J0AK13

Proteomes

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain4-242Endonuclease/exonuclease/phosphatase

Sequence similarities

Belongs to the DNA repair enzymes AP/ExoA family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    250
  • Mass (Da)
    28,975
  • Last updated
    2021-04-07 v1
  • Checksum
    B56695AAB8B6AA98
MKFISWNVNGLRAIVGKGFNDIFANFDADFFCLQEIKLQEGQLDINFEGYKAYYNYAERKGYSGTAIFTRHEPLSVTRGIGMERHDTEGRVVTLEYPDFYLVNVYTPNSQSELARLDYRMEWEEEFLKYIKSLDAVKPVIICGDMNVAHREIDLANPKSNRRNPGFTDEERDAMSRMLESGFVDTFRHLHPELAGAYSWWSYRGRAREKNVGWRIDYFLVSARLADSINNAEIHHDICGSDHCPVSLDLN

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BLLZ01000053
EMBL· GenBank· DDBJ
GFI13700.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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