A0A7I6HQN2 · A0A7I6HQN2_9CHIR
- ProteinHexokinase-1
- GeneHK1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids705 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
Catalytic activity
- D-fructose + ATP = D-fructose 6-phosphate + ADP + H+This reaction proceeds in the forward direction.
Pathway
Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.
Carbohydrate metabolism; hexose metabolism.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | mitochondrial outer membrane | |
Molecular Function | ATP binding | |
Molecular Function | D-glucose binding | |
Molecular Function | fructokinase activity | |
Molecular Function | glucokinase activity | |
Molecular Function | mannokinase activity | |
Biological Process | glucose metabolic process | |
Biological Process | glycolytic process | |
Biological Process | inflammatory response | |
Biological Process | innate immune response | |
Biological Process | intracellular glucose homeostasis |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHexokinase-1
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Chiroptera > Yinpterochiroptera > Rhinolophoidea > Rhinolophidae > Rhinolophinae > Rhinolophus
Accessions
- Primary accessionA0A7I6HQN2
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion outer membrane ; Peripheral membrane protein
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 5-79 | Hexokinase N-terminal | ||||
Sequence: DKKLPVGLTFSFPCRQSKIDEGILITWTKRFKVSGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGY | ||||||
Domain | 86-319 | Hexokinase C-terminal | ||||
Sequence: VGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTEWGAFGDDGALEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTNDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVAVQHVCTIVSFRSANLVAATLGTILNRLRNNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAV | ||||||
Domain | 330-527 | Hexokinase N-terminal | ||||
Sequence: IEETLAHFSLTKEMLLEVKRRMRTEMDMGLQKQTNDKAVVKMLPSFVRSTPDGTEHGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPVEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCKQTSLDAGILITWTKGFKATDCVGHDVATLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAY | ||||||
Domain | 534-705 | Hexokinase C-terminal | ||||
Sequence: VGLIVGTGSNACYMEEMKNVEMLEGNQGRMCINMEWGAFGDNGCLDDIRTNYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISEPLKTRGIFQTKYLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSKRAAQLCGAGMAAVVDKI |
Sequence similarities
Belongs to the hexokinase family.
Family and domain databases
Sequence
- Sequence statusFragment
- Length705
- Mass (Da)78,529
- Last updated2021-04-07 v1
- ChecksumE57906B7BA6DDD66
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: K | ||||||
Non-terminal residue | 705 | |||||
Sequence: I |