A0A7G9Z323 · A0A7G9Z323_9EURY
- ProteinNicotinate-nucleotide pyrophosphorylase [carboxylating]
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids273 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Involved in the catabolism of quinolinic acid (QA).
Catalytic activity
- nicotinate beta-D-ribonucleotide + CO2 + diphosphate = quinolinate + 5-phospho-alpha-D-ribose 1-diphosphate + 2 H+
Pathway
Cofactor biosynthesis; NAD+ biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 88 | substrate | ||||
Sequence: R | ||||||
Binding site | 123-125 | substrate | ||||
Sequence: TRK | ||||||
Binding site | 147 | substrate | ||||
Sequence: R | ||||||
Binding site | 157 | substrate | ||||
Sequence: K | ||||||
Binding site | 186 | substrate | ||||
Sequence: E | ||||||
Binding site | 207 | substrate | ||||
Sequence: D | ||||||
Binding site | 235-237 | substrate | ||||
Sequence: SGG | ||||||
Binding site | 256-258 | substrate | ||||
Sequence: IGM |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | nicotinate-nucleotide diphosphorylase (carboxylating) activity | |
Biological Process | NAD biosynthetic process | |
Biological Process | quinolinate catabolic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNicotinate-nucleotide pyrophosphorylase [carboxylating]
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageArchaea > Euryarchaeota > Stenosarchaea group > Methanomicrobia > Methanosarcinales
Accessions
- Primary accessionA0A7G9Z323
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Subunit
Hexamer formed by 3 homodimers.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 26-98 | Quinolinate phosphoribosyl transferase N-terminal | ||||
Sequence: TSCKAEIQVKEEGVLAGLEEVKQIFDYLSVQYSTEFEDGARLKSGDIILTSSGAGAKILKAERLVLNFLGRMS | ||||||
Domain | 100-270 | Quinolinate phosphoribosyl transferase C-terminal | ||||
Sequence: VATLTDRCVNEVRAVNERVLVAGTRKTTPGFRKYEKKAITIGGGDPHRFGLYEAVIIKDNYIKLMGLESAIKRAKEKVSFTRKIEVEVESVEDALSVAELDVDIIMLDNMSAAEVRTCVKLLNERAVRDRVLVEASGGIDMANIKEFASTGVDVISIGMITHSAKWLGFSM |
Sequence similarities
Belongs to the NadC/ModD family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length273
- Mass (Da)30,131
- Last updated2021-02-10 v1
- Checksum2D20C3FF189BC16F