A0A7D9H0T4 · A0A7D9H0T4_DEKBR
- ProteinMediator of RNA polymerase II transcription subunit 1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids529 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | mediator complex | |
Molecular Function | transcription coregulator activity | |
Biological Process | positive regulation of transcription by RNA polymerase II |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameMediator of RNA polymerase II transcription subunit 1
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Pichiaceae > Brettanomyces
Accessions
- Primary accessionA0A7D9H0T4
Proteomes
Subcellular Location
Structure
Family & Domains
Features
Showing features for domain, compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 15-458 | Mediator complex subunit Med1 | ||||
Sequence: ISDILLKRPGKVCIDSIKRLSNIYGFETFTDTLKVDTKPGSIEKNLVYTIESHAGTPIGPDSEDQLVHRLSLSGKILLIDIDFYKDKVRAVSISSAINIQPIEGKLYDFLKGSDRFDSVQRILLRNLQNATLDQFNKNLRILSQFDRLSMNSPNDLFNFFNQLAYNLVCAHNYDVEILGVKSKEEFKGFKSHPLTLEEAKIDTEAGYSGIGQLLMNQQNKIGLFLQYWEDNRFVNRQLDQDKDIQTQESLNPYQIHFKITENVHSERSEHADSESPAVSASEKDPDAMDVAESTTENGNGSDLKFKWFQDGRWTISQADTILNSNLELLVLEVCPSVWIPEDMLMELGIDRYEVRSNDNDFFNDNQHQDLKDPVLDGLYMCVNRQHSMDLDLAAGSKQFRLEFLVGCPMVKIFKITIEHMNKISALLGNLRTWCLVNSIMRNLV | ||||||
Compositional bias | 277-304 | Basic and acidic residues | ||||
Sequence: VHSERSEHADSESPAVSASEKDPDAMDV | ||||||
Region | 277-311 | Disordered | ||||
Sequence: VHSERSEHADSESPAVSASEKDPDAMDVAESTTEN |
Sequence similarities
Belongs to the Mediator complex subunit 1 family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length529
- Mass (Da)60,411
- Last updated2021-02-10 v1
- ChecksumC40140FB305919F0
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 277-304 | Basic and acidic residues | ||||
Sequence: VHSERSEHADSESPAVSASEKDPDAMDV |
Keywords
- Technical term