A0A7C9MGE2 · A0A7C9MGE2_9RHOB

  • Protein
    Protein translocase subunit SecA
  • Gene
    secA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • ATP + H2O + cellular proteinSide 1 = ADP + phosphate + cellular proteinSide 2.
    EC:7.4.2.8 (UniProtKB | ENZYME | Rhea)

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Features

Showing features for binding site.

1899100200300400500600700800
TypeIDPosition(s)Description
Binding site89ATP (UniProtKB | ChEBI)
Binding site107-111ATP (UniProtKB | ChEBI)
Binding site502ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcell envelope Sec protein transport complex
Cellular Componentcytosol
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Biological Processintracellular protein transmembrane transport
Biological Processprotein import
Biological Processprotein targeting
Biological Processprotein transport by the Sec complex

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein translocase subunit SecA
  • EC number

Gene names

    • Name
      secA
    • ORF names
      GQ651_10615

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • GH1-50
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Rhodobacterales > Paracoccaceae > Kangsaoukella

Accessions

  • Primary accession
    A0A7C9MGE2

Proteomes

Subcellular Location

Cell membrane
; Peripheral membrane protein
Cytoplasm
Membrane
; Peripheral membrane protein
Note: Distribution is 50-50.

Keywords

Interaction

Subunit

Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain5-614SecA family profile
Domain91-249Helicase ATP-binding
Domain427-630Helicase C-terminal

Sequence similarities

Belongs to the SecA family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    899
  • Mass (Da)
    100,565
  • Last updated
    2021-02-10 v1
  • Checksum
    FA3154D6D61B703D
MLGFGTIAKKIFGTTNDRRVRAVQPIVDRINALEAEFAALSDEGLKEKTAEFRDRIAKGEDLDDILPEAFANCREGAKRALGLRAFDVQLIGGYFLHSGDIAEMKTGEGKTLVATFPAYLNALTGKGVHIVTVNDYLAKRDAEWMGKVYGALGMTTGVVYPQQPEDEKKAAYACDITYATNNELGFDYLRDNMKMQLSEMAQRGHYFAIVDEVDSILIDEARTPLIISGPAQDRSELYITIDKIIPELLEEHFTLDEKTRNVTYTDEGNEFLEERLHGAGLLPEDHTLYDPESTTIVHHVNQGLRAHKLFQKDKDYIVRDNQVVLIDEFTGRMMPGRRLSDGLHQAIEAKEGVAIQPENVTLASVTFQNYFRLYEKLAGMTGTASTEAEEFQEIYGLGVVEIPTNKPVARVDEDDQIYRTADEKYKAIVQEIKAANERGQPVLVGTTSIERSEFLSGLLQAENVPHNVLNARQHEQEAQIVADAGKPDAVTIATNMAGRGTDIQLGGNVEMRVMQAMAADPEADPEALRNRIEAEVAGDKAKVLEAGGLYVLATERHESRRIDNQLRGRSGRQGDPGRSSFYLSLEDDLMRIFGSERLDKVLSTLGMQEGEAIKHPWVNKSLERAQAKVEGRNFDIRKQLLKFDDVMNEQRKVIFSQRREIMEADDLEEIAQDMRHNVIDDLVHVHMPPKSYADQWDTEGLKAEIEKEIGISVPVVEWADEEGVDDEVIRERLYEASDVHMAAKAEAFGAEQMRSIEKQLILQTIDAKWREHLLTLEHLRSVVGFRSYAQRDPLNEYKSEAFQLFEGLLDGLRGEVTQKLAHIRPLTQEEQEAMLAQMTGQAKAAEAAASPERKLPAPTQEAIEAGFVEDDPTTWGNPGRNDPCPCGSGNKFKHCHGAL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
WUPT01000002
EMBL· GenBank· DDBJ
MXQ08296.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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