A0A7C3LR15 · A0A7C3LR15_9CREN

  • Protein
    2-(3-amino-3-carboxypropyl)histidine synthase
  • Gene
    dph2
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Pathway

Protein modification; peptidyl-diphthamide biosynthesis.

GO annotations

AspectTerm
Molecular Function2-(3-amino-3-carboxypropyl)histidine synthase activity
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functionmetal ion binding
Biological Processprotein histidyl modification to diphthamide

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    2-(3-amino-3-carboxypropyl)histidine synthase
  • EC number

Gene names

    • Name
      dph2
    • ORF names
      ENX99_05300

Organism names

Accessions

  • Primary accession
    A0A7C3LR15

Family & Domains

Sequence similarities

Belongs to the DPH1/DPH2 family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    337
  • Mass (Da)
    38,170
  • Last updated
    2020-12-02 v1
  • Checksum
    8C8BAF03C2CA325E
MSSPKNLFLDYYYIDVSELSRVVKERKPSRILLQVPEGFKNRSYEIIDYLRGILGDVEIHIDAGPSFGSCLIDVGVTEKYDLVIHLGHRRYPYWNPPGNVVYVDLQSRTELDREVLASLINDLRKHGYVRLAVYTTAQHVDLTKDLIKQLRSNGFEVVNNGVEVVFGCWFSSLDAVKNYVDAFLVVAGGKFHALGVGLRISGSKEVVSLDPYENTYKFLGEYVSRVLKTRFAKIMKSLDAVSWLIIAGSGGQYRPWIINELAKLITDSGGKYYVAVTSYLTRDLLIDVDSSMLDAIVITSCPRLPIEDFHDYEKPVLTPGEAFMALKKVFEPYVFPW

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DTQE01000280
EMBL· GenBank· DDBJ
HFT82256.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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