A0A7C3LR15 · A0A7C3LR15_9CREN
- Protein2-(3-amino-3-carboxypropyl)histidine synthase
- Genedph2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids337 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).
Catalytic activity
- L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-methyl-5'-thioadenosine + H+
Cofactor
Pathway
Protein modification; peptidyl-diphthamide biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 2-(3-amino-3-carboxypropyl)histidine synthase activity | |
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | metal ion binding | |
Biological Process | protein histidyl modification to diphthamide |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name2-(3-amino-3-carboxypropyl)histidine synthase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageArchaea > Thermoproteota > Thermoprotei > Desulfurococcales > Desulfurococcaceae
Accessions
- Primary accessionA0A7C3LR15
Structure
Sequence
- Sequence statusComplete
- Length337
- Mass (Da)38,170
- Last updated2020-12-02 v1
- Checksum8C8BAF03C2CA325E