A0A6P1RB25 · A0A6P1RB25_9BRAD

Function

function

Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme.

Catalytic activity

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis.

GO annotations

AspectTerm
Molecular Functionmetal ion binding
Molecular Functiontransferase activity
Biological Processthiamine biosynthetic process

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Thiamine pyrimidine synthase

Gene names

    • ORF names
      EI171_32780

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • LCT2
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Nitrobacteraceae > Bradyrhizobium

Accessions

  • Primary accession
    A0A6P1RB25

Proteomes

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-24
ChainPRO_502672398025-338Thiamine pyrimidine synthase

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain43-255SsuA/THI5-like

Sequence similarities

Belongs to the NMT1/THI5 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    338
  • Mass (Da)
    36,481
  • Last updated
    2020-10-07 v1
  • Checksum
    F723EC435943D0AB
MLSRRHAFFALSAIALATGSLVTAAPAAELQKASLRLKWLPQAQFAGFYVAAAKGYYKAEGIDLTINPGGPNLLTENLVATGADTFGLSGGTDSVFAARDKGLPIVCIGVSHQITPFIFVTRKDGPVKTIQDFKGKTVTTWFTGANHVLNGMLAKEGIKPDELKIQPQQVSVTPFVDGSVDVVTATYYNEFYTIQSRMPKDSLKTFVAEDYGITFPRDTLIVAEATAKEKPELVKAFLRASLKGWKDAFADPKGAVDTVMAAAPTLDRAQQEFMLTEVKRLMTAGAAAKNGMFWIDADAVKTAHDFFLKYGVISKPLDLAAAYDASFIQSVPLADRLP

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP034432
EMBL· GenBank· DDBJ
QHP71636.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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