A0A6H0WMS6 · A0A6H0WMS6_9BACI

  • Protein
    Diaminopimelate epimerase
  • Gene
    dapF
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1.

Features

Showing features for binding site, active site, site.

TypeIDPosition(s)Description
Binding site14substrate
Binding site67substrate
Active site76Proton donor
Binding site77-78substrate
Binding site166substrate
Site168Could be important to modulate the pK values of the two catalytic cysteine residues
Binding site199substrate
Site217Could be important to modulate the pK values of the two catalytic cysteine residues
Binding site217-218substrate
Active site226Proton acceptor
Binding site227-228substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functiondiaminopimelate epimerase activity
Biological Processlysine biosynthetic process via diaminopimelate

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Diaminopimelate epimerase
  • EC number
  • Short names
    DAP epimerase
  • Alternative names
    • PLP-independent amino acid racemase

Gene names

    • Name
      dapF
    • ORF names
      G4P54_16395

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • EA-CB0015
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Bacillales > Bacillaceae > Bacillus

Accessions

  • Primary accession
    A0A6H0WMS6

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the diaminopimelate epimerase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    284
  • Mass (Da)
    30,835
  • Last updated
    2021-02-10 v1
  • Checksum
    1344817643EBEB4A
MNSFRFTKMHGLGNSYIYVNQFEEQLPEEKLSEIAIQVSSVYTGIGSDGMILICPSDKAPVKMRIFNNDGSEGKNCGNGLRCVAKYAYEHKLVEETSFLIETLSGLVKAEVQTENGKVNVVTVDMGEPRLTKAELPMLGGGKEHTINETMTFGEAELTGTAVSMGNPHIVFPIADIEQAPLTTLGPVIEKDPRFPEGINVEFVEIVNEHELHFRVWERGSGITQACGTGACAAAVASVLNGISKRNQDITVHLAGGDLVINWKDNGHVMMTGPAETVCEGVYFL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP048852
EMBL· GenBank· DDBJ
QIW81249.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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