A0A6G8ALC1 · A0A6G8ALC1_9ENTE

  • Protein
    D-alanine--D-alanyl carrier protein ligase
  • Gene
    dltA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Pathway

Cell wall biogenesis; lipoteichoic acid biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site151-152ATP (UniProtKB | ChEBI)
Binding site196D-alanine (UniProtKB | ChEBI)
Binding site291-296ATP (UniProtKB | ChEBI)
Binding site382ATP (UniProtKB | ChEBI)
Binding site393-396ATP (UniProtKB | ChEBI)
Binding site491ATP (UniProtKB | ChEBI)
Binding site491D-alanine (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular FunctionD-alanine [D-alanyl carrier protein] ligase activity
Biological Processlipoteichoic acid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    D-alanine--D-alanyl carrier protein ligase
  • EC number
  • Short names
    DCL
  • Alternative names
    • D-alanine--poly(phosphoribitol) ligase subunit 1
    • D-alanine-activating enzyme
      (DAE
      )

Gene names

    • Name
      dltA
    • ORF names
      G7081_01130

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • HDW17A
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Lactobacillales > Enterococcaceae > Vagococcus

Accessions

  • Primary accession
    A0A6G8ALC1

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain11-359AMP-dependent synthetase/ligase
Domain413-491AMP-binding enzyme C-terminal

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family. DltA subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    503
  • Mass (Da)
    56,766
  • Last updated
    2020-08-12 v1
  • Checksum
    5A2EA9C310B09F9D
MSRNFIINQIDEWAKKDPERVCFKDGESSYSYKQLKRDSDTLANHFINSLEKNEPILIFGGIYYEMVVSFLAAMKAGHPYIPVDSQTPLDRVEMIISVAKPSCIIAWDELSIDTTTKFINRVQAESILRDDKSIELKNVISGDDVMYIIFTSGTTGVPKGVQITFNNLTDHLDWLMNNFGFEEGDKFLAQTSYSFDVSVMITYPCLLNGGVLNPVSKELIGNFNDLFIALKKMDLNIWISTPSFVEICLLDPNFNGDNYPNLKSFILAGEELKHSLAETLVNRFPNAETINAYGPTEATIIVTKMVITPELLAKSERLPIGEIKTGTGMYIVDDEGNKLPDGQVGELIIDGPTISPGYLNNPEKTAEAFFDMDGIPSYHSGDAAYIKDGIVYYQGRIDFQIKLHGYRIELEDVEHNLNKVSYVKTCTVVPKYKEHKVQQLVAYVVANPHDFEKDFKLSKAIKEEMKHHVMDYMIPQKFVYVDALPLTPNGKVDRKKLIAEVNN

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP049886
EMBL· GenBank· DDBJ
QIL45787.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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