A0A6A1Z7X8 · A0A6A1Z7X8_9LACO

  • Protein
    Phospho-N-acetylmuramoyl-pentapeptide-transferase
  • Gene
    mraY
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site171Mg2+ (UniProtKB | ChEBI)
Binding site231Mg2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionmetal ion binding
Molecular Functionphospho-N-acetylmuramoyl-pentapeptide-transferase activity
Molecular FunctionUDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity
Biological Processcell division
Biological Processcell wall organization
Biological Processpeptidoglycan biosynthetic process
Biological Processregulation of cell shape

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phospho-N-acetylmuramoyl-pentapeptide-transferase
  • EC number
  • Alternative names
    • UDP-MurNAc-pentapeptide phosphotransferase

Gene names

    • Name
      mraY
    • ORF names
      F8251_02565

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • BIO6272
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Lactobacillales > Lactobacillaceae > Lactobacillus

Accessions

  • Primary accession
    A0A6A1Z7X8

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane6-26Helical
Transmembrane54-75Helical
Transmembrane81-102Helical
Transmembrane114-133Helical
Transmembrane139-164Helical
Transmembrane176-195Helical
Transmembrane201-220Helical
Transmembrane227-248Helical
Transmembrane254-275Helical
Transmembrane304-321Helical

Keywords

Family & Domains

Sequence similarities

Belongs to the glycosyltransferase 4 family. MraY subfamily.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    322
  • Mass (Da)
    35,537
  • Last updated
    2020-06-17 v1
  • Checksum
    314CE03F01F59958
MNMMLASCIALVSSLVLTVIFIPLLIKFMRSHHEGQEIRDEGPKWHQKKSGTPTMGGTVFVIAAVISVIWVAAMQHSLNKVIWILVISLLGYGIIGFLDDGIKLYFKRNLGLRAWQKLALQIIIAILIVLIATSDHFQFGLYIPFAGVVHSLVLFVAFIIFWLVGFSNAVNLSDGLDGLATGLSVVAYGTYAYIAFKQKNFAVLAFCMSVIGGLIAFFIFNHKPAKIFMGDAGSLALGGGLATISIMLNRPWSLLLVGIVFVCETASVILQVISFQTTGKRIFKMTPIHHHFEMLGWSEWKVDIVFWLVGLIGSILYLVIWG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
WBOB01000007
EMBL· GenBank· DDBJ
KAB1977720.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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