A0A660RFA2 · A0A660RFA2_9THEM

  • Protein
    Pyridoxal 5'-phosphate synthase subunit PdxT
  • Gene
    pdxT
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site46-48L-glutamine (UniProtKB | ChEBI)
Active site78Nucleophile
Binding site105L-glutamine (UniProtKB | ChEBI)
Binding site134-135L-glutamine (UniProtKB | ChEBI)
Active site170
Active site170Charge relay system
Active site172
Active site172Charge relay system

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentglutaminase complex
Molecular Functionglutaminase activity
Molecular Functionpyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
Biological Processglutamine catabolic process
Biological Processpyridoxal phosphate biosynthetic process
Biological Processpyridoxine metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Pyridoxal 5'-phosphate synthase subunit PdxT
  • EC number
  • Alternative names
    • Pdx2
    • Pyridoxal 5'-phosphate synthase glutaminase subunit
      (EC:3.5.1.2
      ) . EC:3.5.1.2 (UniProtKB | ENZYME | Rhea)

Gene names

    • Name
      pdxT
    • ORF names
      DRP50_05220

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • B3_G13
  • Taxonomic lineage
    Bacteria > Thermotogota > Thermotogae > Thermotogales > Thermotogaceae > Thermotoga

Accessions

  • Primary accession
    A0A660RFA2

Proteomes

Subcellular Location

Interaction

Subunit

In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

Family & Domains

Sequence similarities

Belongs to the glutaminase PdxT/SNO family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    199
  • Mass (Da)
    22,101
  • Last updated
    2020-04-22 v1
  • Checksum
    7EAA7769292E462E
MIIGVLSMQGDIREHIKMLDACGVEAVRVKTEETLTNVDGLIIPGGESTTIIRLLNSSGLRSLLIRRANEGLPVWGTCAGMIVVAKSPINNRDRGLGLIDIQVKRNAFGRQVDSFEVDIPLDVIGKPPYRCIFIRAPVISNAGKNVELLAQHNGFAVMGKERNVLVTSFHPELTNDKRIHKYFINMVKKYIESHEKLNT

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QNAT01000146
EMBL· GenBank· DDBJ
RKX53869.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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