A0A602GY58 · A0A602GY58_SALER
- ProteinBifunctional purine biosynthesis protein PurH
- GenepurH
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids529 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
Catalytic activity
- (6R)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = (6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
Pathway
Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.
Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | IMP cyclohydrolase activity | |
Molecular Function | phosphoribosylaminoimidazolecarboxamide formyltransferase activity | |
Biological Process | 'de novo' IMP biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameBifunctional purine biosynthesis protein PurH
Including 2 domains:
- Recommended namePhosphoribosylaminoimidazolecarboxamide formyltransferase
- EC number
- Alternative names
- Recommended nameIMP cyclohydrolase
- EC number
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Salmonella
Accessions
- Primary accessionA0A602GY58
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-148 | MGS-like | ||||
Sequence: MQQRRSVRRALLSVSDKAGIVEFAQALSARGVELLSTGGTARLLAEKGLPVTEVSDYTGFPEMMDGRVKTLHPKVHGGILGRRGQDDGIMEQHGIAPIDMVVVNLYPFAETVAHVGCSLEDAVENIDIGGPTMVRSAAKNHKDVAIVV |
Domain
The IMP cyclohydrolase activity resides in the N-terminal region.
Sequence similarities
Belongs to the PurH family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length529
- Mass (Da)57,326
- Last updated2020-04-22 v1
- Checksum948E65CC450090F3