A0A5N6JYS6 · A0A5N6JYS6_MONLA
- ProteinClass E vacuolar protein-sorting machinery protein HSE1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids733 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | endosome membrane | |
Cellular Component | ESCRT-0 complex | |
Molecular Function | phosphatidylinositol binding | |
Molecular Function | ubiquitin binding | |
Biological Process | protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameClass E vacuolar protein-sorting machinery protein HSE1
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Leotiomycetes > Helotiales > Sclerotiniaceae > Monilinia
Accessions
- Primary accessionA0A5N6JYS6
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Endosome membrane ; Peripheral membrane protein
Keywords
- Cellular component
Interaction
Subunit
Component of the ESCRT-0 complex composed of HSE1 and VPS27.
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 16-144 | VHS | ||||
Sequence: ATDENLTSENWEYIMDVCDKVTGEDSGAKDAVASMIKRLAHRNANVQLYTLELANALSQNCGAKIHRELASRAFTDALLRLANDRNTHQQVKAKILERMAEWAGMFKDPDLGIMNDQYHRLKSQNPNLH | ||||||
Region | 136-158 | Disordered | ||||
Sequence: LKSQNPNLHPPSAPSKSRLTDLD | ||||||
Region | 174-210 | Disordered | ||||
Sequence: IQDKSSQPKPAQPSGSSADPAQSPEVVQPQQVPSGTT | ||||||
Domain | 212-271 | SH3 | ||||
Sequence: ATVSRVRALYDFQATDADELQFRKGDIIAVVGSVYKDWWRGSIRGKTGIFPLNYVEKLVD | ||||||
Region | 374-733 | Disordered | ||||
Sequence: YGRPGQVPQGPQGYGYPAQAGRPQQEPQRYYTPSQQHEPPYQRQQSPPGGFPPRNGPAPFYVVAPGQQLPQADGRQPYPGQQPPQADGRQPYPSQSPQADGRQPYPGQQPPQSESQQPYPQRDPTPRIASGSKPPPVQYSTQQPQTGHRPQSTYSNPQELATSVYDTPVQQQNPHPYTAYAETDPYTAAPATAQSSQPYNAYKPPQQPSQPPQQPSQPSQPLYEPSAAPSATQPPQQYSAYNPPQQQSQPSEPSFEPPAVPPSTQSPQQYGAYKPPQQPSQPPQPTYEPPAPPSQIPSPVQSSPYPVPEDTRTALPNQGQYKAYQRPDSSDSNQDLSNAPSAPPAEASNPADFYRQNTAY | ||||||
Compositional bias | 398-416 | Polar residues | ||||
Sequence: QEPQRYYTPSQQHEPPYQR | ||||||
Compositional bias | 418-432 | Pro residues | ||||
Sequence: QSPPGGFPPRNGPAP | ||||||
Compositional bias | 460-496 | Polar residues | ||||
Sequence: DGRQPYPSQSPQADGRQPYPGQQPPQSESQQPYPQRD | ||||||
Compositional bias | 507-551 | Polar residues | ||||
Sequence: PPPVQYSTQQPQTGHRPQSTYSNPQELATSVYDTPVQQQNPHPYT | ||||||
Compositional bias | 561-576 | Polar residues | ||||
Sequence: AAPATAQSSQPYNAYK | ||||||
Compositional bias | 577-592 | Pro residues | ||||
Sequence: PPQQPSQPPQQPSQPS | ||||||
Compositional bias | 593-622 | Polar residues | ||||
Sequence: QPLYEPSAAPSATQPPQQYSAYNPPQQQSQ | ||||||
Compositional bias | 623-637 | Pro residues | ||||
Sequence: PSEPSFEPPAVPPST | ||||||
Compositional bias | 649-677 | Pro residues | ||||
Sequence: PQQPSQPPQPTYEPPAPPSQIPSPVQSSP | ||||||
Compositional bias | 678-717 | Polar residues | ||||
Sequence: YPVPEDTRTALPNQGQYKAYQRPDSSDSNQDLSNAPSAPP |
Sequence similarities
Belongs to the STAM family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length733
- Mass (Da)81,394
- Last updated2020-04-22 v1
- ChecksumEC3DBD7374C70B49
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 398-416 | Polar residues | ||||
Sequence: QEPQRYYTPSQQHEPPYQR | ||||||
Compositional bias | 418-432 | Pro residues | ||||
Sequence: QSPPGGFPPRNGPAP | ||||||
Compositional bias | 460-496 | Polar residues | ||||
Sequence: DGRQPYPSQSPQADGRQPYPGQQPPQSESQQPYPQRD | ||||||
Compositional bias | 507-551 | Polar residues | ||||
Sequence: PPPVQYSTQQPQTGHRPQSTYSNPQELATSVYDTPVQQQNPHPYT | ||||||
Compositional bias | 561-576 | Polar residues | ||||
Sequence: AAPATAQSSQPYNAYK | ||||||
Compositional bias | 577-592 | Pro residues | ||||
Sequence: PPQQPSQPPQQPSQPS | ||||||
Compositional bias | 593-622 | Polar residues | ||||
Sequence: QPLYEPSAAPSATQPPQQYSAYNPPQQQSQ | ||||||
Compositional bias | 623-637 | Pro residues | ||||
Sequence: PSEPSFEPPAVPPST | ||||||
Compositional bias | 649-677 | Pro residues | ||||
Sequence: PQQPSQPPQPTYEPPAPPSQIPSPVQSSP | ||||||
Compositional bias | 678-717 | Polar residues | ||||
Sequence: YPVPEDTRTALPNQGQYKAYQRPDSSDSNQDLSNAPSAPP |
Keywords
- Technical term