A0A5M9N1W2 · A0A5M9N1W2_9EURO
- ProteinUncharacterized protein
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids341 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum | |
Cellular Component | proteasome complex | |
Molecular Function | endopeptidase inhibitor activity | |
Molecular Function | proteasome binding | |
Biological Process | proteasome-mediated ubiquitin-dependent protein catabolic process |
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Aspergillaceae > Aspergillus > Aspergillus subgen. Circumdati
Accessions
- Primary accessionA0A5M9N1W2
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 46-160 | PI31 proteasome regulator N-terminal | ||||
Sequence: SSSDNPSLPSEWNVNDTISFRYAHPRSSMQYLLKINRLGSNAVILALALGDDKPTSFDVTANDFISPSSLPISSSADLPPARLSEVFISPSRLNDLIALFKINVIQKLAPGVYKE | ||||||
Region | 160-341 | Disordered | ||||
Sequence: EGYEVSSQTTRESRERPLPRNPLRDDPIPRPSRPYPLYDPLAAEPRRPVPPGDFAPPGFEDEFEIQRPPRGYPPGWGGRNPLNIGDRDLYPPGLGPHDPLRGGIGPGLAPGGGGMHPTFDDPLFGGDRSNSGYDPQIPPGARYDPVGPGDAPFGPGRRPFGGGGAGGRGAGGGFGGFGGDII | ||||||
Compositional bias | 166-186 | Basic and acidic residues | ||||
Sequence: SQTTRESRERPLPRNPLRDDP | ||||||
Compositional bias | 187-214 | Pro residues | ||||
Sequence: IPRPSRPYPLYDPLAAEPRRPVPPGDFA | ||||||
Domain | 243-307 | PI31 proteasome regulator C-terminal | ||||
Sequence: IGDRDLYPPGLGPHDPLRGGIGPGLAPGGGGMHPTFDDPLFGGDRSNSGYDPQIPPGARYDPVGP |
Sequence similarities
Belongs to the proteasome inhibitor PI31 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length341
- Mass (Da)36,204
- Last updated2020-02-26 v1
- Checksum59E920E78D5CF4BA
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 166-186 | Basic and acidic residues | ||||
Sequence: SQTTRESRERPLPRNPLRDDP | ||||||
Compositional bias | 187-214 | Pro residues | ||||
Sequence: IPRPSRPYPLYDPLAAEPRRPVPPGDFA |