A0A5J6KKQ5 · A0A5J6KKQ5_ARAMA
- ProteinCytochrome c oxidase subunit 1
- GeneCOI
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids200 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Catalytic activity
- 4 Fe(II)-[cytochrome c] + 8 H+(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H+(out) + 2 H2O
4 RHEA-COMP:10350 + 8 H+ (in)CHEBI:15378+ CHEBI:15379 = 4 RHEA-COMP:14399 + 4 H+ (out)CHEBI:15378+ 2 CHEBI:15377
Cofactor
Protein has several cofactor binding sites:
Pathway
Energy metabolism; oxidative phosphorylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | respirasome | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | oxidative phosphorylation |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 1
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Psittaciformes > Psittacidae > Ara
Accessions
- Primary accessionA0A5J6KKQ5
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 12-30 | Helical | ||||
Sequence: ILILPGFGIISHVVAYHAG | ||||||
Transmembrane | 37-58 | Helical | ||||
Sequence: YMGMVWAMLSIGFLGFIVWAHH | ||||||
Transmembrane | 70-94 | Helical | ||||
Sequence: AYFTSATMIIAIPTGIKVFSWLATL | ||||||
Transmembrane | 106-126 | Helical | ||||
Sequence: LWALGFIFLFTIGGLTGIVLA | ||||||
Transmembrane | 146-167 | Helical | ||||
Sequence: YVLSMGAVFAILAGLTHWFPLF | ||||||
Transmembrane | 179-198 | Helical | ||||
Sequence: THFGVMFTGVNLTFFPQHFL |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-200 | Cytochrome oxidase subunit I profile | ||||
Sequence: LFWFFGHPEVYILILPGFGIISHVVAYHAGKKEPFGYMGMVWAMLSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGIKVFSWLATLHGGTIKWDPPMLWALGFIFLFTIGGLTGIVLANSSLDIALHDTYYVVAHFHYVLSMGAVFAILAGLTHWFPLFTGYTLNQTWAKTHFGVMFTGVNLTFFPQHFLGL |
Sequence similarities
Belongs to the heme-copper respiratory oxidase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length200
- Mass (Da)22,391
- Last updated2019-12-11 v1
- Checksum2199FC3DD2D5347C
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: L | ||||||
Non-terminal residue | 200 | |||||
Sequence: L |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
MK642090 EMBL· GenBank· DDBJ | QEV88921.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK642091 EMBL· GenBank· DDBJ | QEV88922.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK642093 EMBL· GenBank· DDBJ | QEV88924.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK642094 EMBL· GenBank· DDBJ | QEV88925.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK642095 EMBL· GenBank· DDBJ | QEV88926.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK642096 EMBL· GenBank· DDBJ | QEV88927.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK642097 EMBL· GenBank· DDBJ | QEV88928.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK642098 EMBL· GenBank· DDBJ | QEV88929.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK642099 EMBL· GenBank· DDBJ | QEV88930.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK642102 EMBL· GenBank· DDBJ | QEV88933.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK642103 EMBL· GenBank· DDBJ | QEV88934.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK642105 EMBL· GenBank· DDBJ | QEV88936.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK642112 EMBL· GenBank· DDBJ | QEV88943.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK642114 EMBL· GenBank· DDBJ | QEV88945.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK642119 EMBL· GenBank· DDBJ | QEV88950.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK642120 EMBL· GenBank· DDBJ | QEV88951.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK642121 EMBL· GenBank· DDBJ | QEV88952.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK642122 EMBL· GenBank· DDBJ | QEV88953.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK642123 EMBL· GenBank· DDBJ | QEV88954.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK642124 EMBL· GenBank· DDBJ | QEV88955.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK642125 EMBL· GenBank· DDBJ | QEV88956.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK642126 EMBL· GenBank· DDBJ | QEV88957.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK642127 EMBL· GenBank· DDBJ | QEV88958.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK642128 EMBL· GenBank· DDBJ | QEV88959.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK642129 EMBL· GenBank· DDBJ | QEV88960.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK642133 EMBL· GenBank· DDBJ | QEV88964.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK642134 EMBL· GenBank· DDBJ | QEV88965.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK642135 EMBL· GenBank· DDBJ | QEV88966.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK642146 EMBL· GenBank· DDBJ | QEV88977.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK642147 EMBL· GenBank· DDBJ | QEV88978.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK642151 EMBL· GenBank· DDBJ | QEV88982.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK642152 EMBL· GenBank· DDBJ | QEV88983.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK642153 EMBL· GenBank· DDBJ | QEV88984.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK642157 EMBL· GenBank· DDBJ | QEV88988.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK642158 EMBL· GenBank· DDBJ | QEV88989.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK642159 EMBL· GenBank· DDBJ | QEV88990.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK642160 EMBL· GenBank· DDBJ | QEV88991.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK642161 EMBL· GenBank· DDBJ | QEV88992.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK642162 EMBL· GenBank· DDBJ | QEV88993.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK642163 EMBL· GenBank· DDBJ | QEV88994.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK642164 EMBL· GenBank· DDBJ | QEV88995.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK642165 EMBL· GenBank· DDBJ | QEV88996.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK642166 EMBL· GenBank· DDBJ | QEV88997.1 EMBL· GenBank· DDBJ | Genomic DNA |