A0A5J6KKQ5 · A0A5J6KKQ5_ARAMA

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Cu cation (UniProtKB | Rhea| CHEBI:23378 )

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespirasome
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processoxidative phosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Strains
    • ANica8
    • ANica9
    • ApNica2
    • ApNica3
    • Beliz1
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Psittaciformes > Psittacidae > Ara

Accessions

  • Primary accession
    A0A5J6KKQ5

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane12-30Helical
Transmembrane37-58Helical
Transmembrane70-94Helical
Transmembrane106-126Helical
Transmembrane146-167Helical
Transmembrane179-198Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-200Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    200
  • Mass (Da)
    22,391
  • Last updated
    2019-12-11 v1
  • Checksum
    2199FC3DD2D5347C
LFWFFGHPEVYILILPGFGIISHVVAYHAGKKEPFGYMGMVWAMLSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGIKVFSWLATLHGGTIKWDPPMLWALGFIFLFTIGGLTGIVLANSSLDIALHDTYYVVAHFHYVLSMGAVFAILAGLTHWFPLFTGYTLNQTWAKTHFGVMFTGVNLTFFPQHFLGL

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue200

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MK642090
EMBL· GenBank· DDBJ
QEV88921.1
EMBL· GenBank· DDBJ
Genomic DNA
MK642091
EMBL· GenBank· DDBJ
QEV88922.1
EMBL· GenBank· DDBJ
Genomic DNA
MK642093
EMBL· GenBank· DDBJ
QEV88924.1
EMBL· GenBank· DDBJ
Genomic DNA
MK642094
EMBL· GenBank· DDBJ
QEV88925.1
EMBL· GenBank· DDBJ
Genomic DNA
MK642095
EMBL· GenBank· DDBJ
QEV88926.1
EMBL· GenBank· DDBJ
Genomic DNA
MK642096
EMBL· GenBank· DDBJ
QEV88927.1
EMBL· GenBank· DDBJ
Genomic DNA
MK642097
EMBL· GenBank· DDBJ
QEV88928.1
EMBL· GenBank· DDBJ
Genomic DNA
MK642098
EMBL· GenBank· DDBJ
QEV88929.1
EMBL· GenBank· DDBJ
Genomic DNA
MK642099
EMBL· GenBank· DDBJ
QEV88930.1
EMBL· GenBank· DDBJ
Genomic DNA
MK642102
EMBL· GenBank· DDBJ
QEV88933.1
EMBL· GenBank· DDBJ
Genomic DNA
MK642103
EMBL· GenBank· DDBJ
QEV88934.1
EMBL· GenBank· DDBJ
Genomic DNA
MK642105
EMBL· GenBank· DDBJ
QEV88936.1
EMBL· GenBank· DDBJ
Genomic DNA
MK642112
EMBL· GenBank· DDBJ
QEV88943.1
EMBL· GenBank· DDBJ
Genomic DNA
MK642114
EMBL· GenBank· DDBJ
QEV88945.1
EMBL· GenBank· DDBJ
Genomic DNA
MK642119
EMBL· GenBank· DDBJ
QEV88950.1
EMBL· GenBank· DDBJ
Genomic DNA
MK642120
EMBL· GenBank· DDBJ
QEV88951.1
EMBL· GenBank· DDBJ
Genomic DNA
MK642121
EMBL· GenBank· DDBJ
QEV88952.1
EMBL· GenBank· DDBJ
Genomic DNA
MK642122
EMBL· GenBank· DDBJ
QEV88953.1
EMBL· GenBank· DDBJ
Genomic DNA
MK642123
EMBL· GenBank· DDBJ
QEV88954.1
EMBL· GenBank· DDBJ
Genomic DNA
MK642124
EMBL· GenBank· DDBJ
QEV88955.1
EMBL· GenBank· DDBJ
Genomic DNA
MK642125
EMBL· GenBank· DDBJ
QEV88956.1
EMBL· GenBank· DDBJ
Genomic DNA
MK642126
EMBL· GenBank· DDBJ
QEV88957.1
EMBL· GenBank· DDBJ
Genomic DNA
MK642127
EMBL· GenBank· DDBJ
QEV88958.1
EMBL· GenBank· DDBJ
Genomic DNA
MK642128
EMBL· GenBank· DDBJ
QEV88959.1
EMBL· GenBank· DDBJ
Genomic DNA
MK642129
EMBL· GenBank· DDBJ
QEV88960.1
EMBL· GenBank· DDBJ
Genomic DNA
MK642133
EMBL· GenBank· DDBJ
QEV88964.1
EMBL· GenBank· DDBJ
Genomic DNA
MK642134
EMBL· GenBank· DDBJ
QEV88965.1
EMBL· GenBank· DDBJ
Genomic DNA
MK642135
EMBL· GenBank· DDBJ
QEV88966.1
EMBL· GenBank· DDBJ
Genomic DNA
MK642146
EMBL· GenBank· DDBJ
QEV88977.1
EMBL· GenBank· DDBJ
Genomic DNA
MK642147
EMBL· GenBank· DDBJ
QEV88978.1
EMBL· GenBank· DDBJ
Genomic DNA
MK642151
EMBL· GenBank· DDBJ
QEV88982.1
EMBL· GenBank· DDBJ
Genomic DNA
MK642152
EMBL· GenBank· DDBJ
QEV88983.1
EMBL· GenBank· DDBJ
Genomic DNA
MK642153
EMBL· GenBank· DDBJ
QEV88984.1
EMBL· GenBank· DDBJ
Genomic DNA
MK642157
EMBL· GenBank· DDBJ
QEV88988.1
EMBL· GenBank· DDBJ
Genomic DNA
MK642158
EMBL· GenBank· DDBJ
QEV88989.1
EMBL· GenBank· DDBJ
Genomic DNA
MK642159
EMBL· GenBank· DDBJ
QEV88990.1
EMBL· GenBank· DDBJ
Genomic DNA
MK642160
EMBL· GenBank· DDBJ
QEV88991.1
EMBL· GenBank· DDBJ
Genomic DNA
MK642161
EMBL· GenBank· DDBJ
QEV88992.1
EMBL· GenBank· DDBJ
Genomic DNA
MK642162
EMBL· GenBank· DDBJ
QEV88993.1
EMBL· GenBank· DDBJ
Genomic DNA
MK642163
EMBL· GenBank· DDBJ
QEV88994.1
EMBL· GenBank· DDBJ
Genomic DNA
MK642164
EMBL· GenBank· DDBJ
QEV88995.1
EMBL· GenBank· DDBJ
Genomic DNA
MK642165
EMBL· GenBank· DDBJ
QEV88996.1
EMBL· GenBank· DDBJ
Genomic DNA
MK642166
EMBL· GenBank· DDBJ
QEV88997.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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