A0A5F2D0F2 · A0A5F2D0F2_9LEPT

  • Protein
    Phosphoribosylformylglycinamidine synthase subunit PurS
  • Gene
    purS
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide: step 1/2.

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionphosphoribosylformylglycinamidine synthase activity
Biological Process'de novo' IMP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoribosylformylglycinamidine synthase subunit PurS
  • EC number
  • Short names
    FGAM synthase
  • Alternative names
    • Formylglycinamide ribonucleotide amidotransferase subunit III
      (FGAR amidotransferase III
      ; FGAR-AT III
      )
    • Phosphoribosylformylglycinamidine synthase subunit III

Gene names

    • Name
      purS
    • ORF names
      EHQ96_16945
      , EHR04_03555
      , ND810_13430

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • 201601121
    • 201601299
    • VSF7
  • Taxonomic lineage
    Bacteria > Spirochaetota > Spirochaetia > Leptospirales > Leptospiraceae > Leptospira

Accessions

  • Primary accession
    A0A5F2D0F2

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.

Family & Domains

Sequence similarities

Belongs to the PurS family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    82
  • Mass (Da)
    9,143
  • Last updated
    2019-11-13 v1
  • Checksum
    93CB8795EC3FCC6E
MFVAKINVTLKESVLDPQGQTVLRTLHDQGKGQVQDLRVGKYIELKLNASSLKEAESIAKEICESVLVNQVIETYKLVVESQ

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAMQQD010000005
EMBL· GenBank· DDBJ
MCW7516165.1
EMBL· GenBank· DDBJ
Genomic DNA
RQHJ01000014
EMBL· GenBank· DDBJ
TGM65508.1
EMBL· GenBank· DDBJ
Genomic DNA
RQHN01000005
EMBL· GenBank· DDBJ
TGM78842.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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