A0A5A4RH76 · A0A5A4RH76_LEIME
- Proteinmannose-6-phosphate isomerase
- Genempi
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids363 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
Catalytic activity
- D-mannose 6-phosphate = D-fructose 6-phosphate
Cofactor
Note: Binds 1 zinc ion per subunit.
Pathway
Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | mannose-6-phosphate isomerase activity | |
Molecular Function | zinc ion binding | |
Biological Process | carbohydrate metabolic process | |
Biological Process | GDP-mannose biosynthetic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namemannose-6-phosphate isomerase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Discoba > Euglenozoa > Kinetoplastea > Metakinetoplastina > Trypanosomatida > Trypanosomatidae > Leishmaniinae > Leishmania
Accessions
- Primary accessionA0A5A4RH76
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 10-123 | Phosphomannose isomerase type I catalytic | ||||
Sequence: GKMFAELWVGTHLNCPSKIADGNAQLLEDFLKQPENKKKYFSEAHQATTFRDTVPYLPKILSIRTALSIQAHPCKKFAEELHAARPDKYKDPNHKPELICALTPFEALCCFRPL | ||||||
Domain | 158-227 | Phosphomannose isomerase type I helical insertion | ||||
Sequence: PATDSDEEKQLLKAMMTNVYAAADDVVTKALRLHLQRIEEKGAQCAEDELFACIYRQYPDDVGCWMVYFL |
Sequence similarities
Belongs to the mannose-6-phosphate isomerase type 1 family.
Family and domain databases
Sequence
- Sequence statusFragment
- Length363
- Mass (Da)40,286
- Last updated2019-11-13 v1
- Checksum80364FFA82424157
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: M | ||||||
Non-terminal residue | 363 | |||||
Sequence: D |