A0A5A4RH76 · A0A5A4RH76_LEIME

  • Protein
    mannose-6-phosphate isomerase
  • Gene
    mpi
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Pathway

Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.

Features

Showing features for binding site, active site.

136350100150200250300350
TypeIDPosition(s)Description
Binding site79Zn2+ (UniProtKB | ChEBI)
Binding site81Zn2+ (UniProtKB | ChEBI)
Binding site106Zn2+ (UniProtKB | ChEBI)
Binding site246Zn2+ (UniProtKB | ChEBI)
Active site265

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionmannose-6-phosphate isomerase activity
Molecular Functionzinc ion binding
Biological Processcarbohydrate metabolic process
Biological ProcessGDP-mannose biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    mannose-6-phosphate isomerase
  • EC number

Gene names

    • Name
      mpi

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • HU6
  • Taxonomic lineage
    Eukaryota > Discoba > Euglenozoa > Kinetoplastea > Metakinetoplastina > Trypanosomatida > Trypanosomatidae > Leishmaniinae > Leishmania

Accessions

  • Primary accession
    A0A5A4RH76

Organism-specific databases

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain10-123Phosphomannose isomerase type I catalytic
Domain158-227Phosphomannose isomerase type I helical insertion

Sequence similarities

Belongs to the mannose-6-phosphate isomerase type 1 family.

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    363
  • Mass (Da)
    40,286
  • Last updated
    2019-11-13 v1
  • Checksum
    80364FFA82424157
MKGLTNDKSGKMFAELWVGTHLNCPSKIADGNAQLLEDFLKQPENKKKYFSEAHQATTFRDTVPYLPKILSIRTALSIQAHPCKKFAEELHAARPDKYKDPNHKPELICALTPFEALCCFRPLGAIIAYLKRIPELAELVGAEAVLGQYMMAPESALPATDSDEEKQLLKAMMTNVYAAADDVVTKALRLHLQRIEEKGAQCAEDELFACIYRQYPDDVGCWMVYFLNYVQMVPGEALFLSDSEPHAYISGDGVEIMACSDNVVRAGLTPKWKDVPTLISMLKYDTTGLASARHEKKIGEDAAQWQVQYYQPPAQFPDFSLYRLQYEHASGKGMTSVTLPTIGLGFCLEGSAKVNGTTVNAGD

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue363

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LC468956
EMBL· GenBank· DDBJ
BBJ01293.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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