A0A564Q6G5 · A0A564Q6G5_9EURY

Function

function

Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.

Caution

Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site8-13NAD+ (UniProtKB | ChEBI)
Binding site40NAD+ (UniProtKB | ChEBI)
Binding site41NADP+ (UniProtKB | ChEBI)
Binding site92-94NAD+ (UniProtKB | ChEBI)
Binding site117-120NAD+ (UniProtKB | ChEBI)
Active site149Proton donor/acceptor
Binding site150(S)-2,3,4,5-tetrahydrodipicolinate (UniProtKB | ChEBI)
Active site153Proton donor
Binding site159-160(S)-2,3,4,5-tetrahydrodipicolinate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function4-hydroxy-tetrahydrodipicolinate reductase
Molecular FunctionNAD binding
Molecular FunctionNADP binding
Molecular Functionoxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor
Biological Processdiaminopimelate biosynthetic process
Biological Processlysine biosynthetic process via diaminopimelate

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    4-hydroxy-tetrahydrodipicolinate reductase
  • EC number
  • Short names
    HTPA reductase

Gene names

    • Name
      dapB
    • ORF names
      MOIL_01395

Organism names

  • Taxonomic identifier
  • Strain
    • Gfbio:mag-sample-2:67c8463b-6cbd-4d56-a398-d795175a9500
  • Taxonomic lineage
    Archaea > Euryarchaeota > Candidatus Methanoliparia > Candidatus Methanoliparales > Candidatus Methanollivieraceae

Accessions

  • Primary accession
    A0A564Q6G5

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain2-120Dihydrodipicolinate reductase N-terminal
Domain123-255Dihydrodipicolinate reductase C-terminal

Sequence similarities

Belongs to the DapB family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    257
  • Mass (Da)
    28,333
  • Last updated
    2019-10-16 v1
  • Checksum
    950449E789EEF050
MINVAVAGANGRMGSLICKDVLEADEVELAVAMDVSGIGEKGNLKIEDAKMMDKIFREVSPKADVYVDFTVADAAVENIETASENGVNLVVGTTGFSKEQEERIERAINGNVSAVISPNFSVGVNVFWKIVKEAAIHLKGYDAEIIESHHRFKKDSPSGTAKKAYDLLCEVWGEREPVYGRSGFSERREEIGMHSIRAGDIVGDHTVLFGGDGERLEITHRAHSREAFASGVLRSIRWLFASEREKKIYTMEDVLEL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CABGHG010000107
EMBL· GenBank· DDBJ
VUT26124.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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