A0A520W2J9 · A0A520W2J9_9ACTN

Function

function

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • ATP + H2O + cellular proteinSide 1 = ADP + phosphate + cellular proteinSide 2.
    EC:7.4.2.8 (UniProtKB | ENZYME | Rhea)

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Features

Showing features for binding site.

1840100200300400500600700800
TypeIDPosition(s)Description
Binding site82ATP (UniProtKB | ChEBI)
Binding site100-104ATP (UniProtKB | ChEBI)
Binding site489ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcell envelope Sec protein transport complex
Cellular Componentcytosol
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Biological Processintracellular protein transmembrane transport
Biological Processprotein import
Biological Processprotein targeting
Biological Processprotein transport by the Sec complex

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein translocase subunit SecA
  • EC number

Gene names

    • Name
      secA
    • ORF names
      EVA28_01280

Organism names

Accessions

  • Primary accession
    A0A520W2J9

Proteomes

Subcellular Location

Cell membrane
; Peripheral membrane protein
Cytoplasm
Membrane
; Peripheral membrane protein
Note: Distribution is 50-50.

Keywords

Interaction

Subunit

Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.

Family & Domains

Features

Showing features for domain, coiled coil, region.

TypeIDPosition(s)Description
Domain1-594SecA family profile
Coiled coil11-38
Domain84-222Helicase ATP-binding
Domain411-593Helicase C-terminal
Region812-840Disordered

Sequence similarities

Belongs to the SecA family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    840
  • Mass (Da)
    95,871
  • Last updated
    2019-10-16 v1
  • Checksum
    0B1964D07DD96E27
MVFDKLLTVGSGKLSKELNSIVDLINKLEEEFEGYSDEAIKDGFQSLKEKVEENILLAEVEGFAYVREAAKRKLDQRHFDVQLFGGLVLLRNKIAEMKTGEGKTLVSTLPVSLMALAGRGVHVVTVNDYLAKRDAEWMGPVYEFLGLSVGLIQAGQVLEEKQNAYKADITYGTNNEFGFDYLRDNMTQNVEQLVQRELTFALIDEVDSILVDESRTPLVLSGRVEESTKWYIQFSKIVKGMKKDVHYEIEESKRQIHPTEIGIEYIEKQLGVENLYEETAVNYLHYLTASLRAKELYSRDVEYIVSNGQLNIVDEFTGRVLEGRRYSEGLHQALEAKEGLKVQDENQTLATITFQNFFRLYGRLAGMTGTAKTEEEELIQIYNLEVIEIPTNMEIARIDNEDVIYKTKESKLNAVVDDIKSRVERGQPVLVGTVSVESSEQISSLLTSQGIIHSVLNAKNHEKEALIIAQAGRSGAVTVATNMAGRGVDIKLGGNPDFVGIEEGKDKVQDLDQVTAEKENKKVLDSGGLYVLGTERHESRRIDNQLRGRSGRQGDPGESRFYISLEDELMRRFQGERIQSIMDKLNLPDDERIEQKMVTKSIERAQAQVESLNFEIRKNVLKFDQVLNQQREVIYKWRKRLLATEENKDLLSEWKDDVLTEIQMDYEQINLSFDTLDDYENQLSELLASVLNDNNKKIFLDSFDSDPKSEAILITNLDTLFNQKMEKDNDFWEIGRMASLSFVDQAWRDHLAEMDHIRTGIGLRAMGQRDPLVEYQKEGYDLFEELVTRVKFSVIRLLFNFEKEILVNSERKEESINKGPVGRNEPCPCGSGKKYKRCHG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
SGYS01000014
EMBL· GenBank· DDBJ
RZP25715.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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