A0A4R3ZCB8 · A0A4R3ZCB8_9ENTR

Function

function

Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions per subunit. One is catalytic and the other provides a structural contribution.

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.

Features

Showing features for active site, binding site.

TypeIDPosition(s)Description
Active site110Proton donor
Binding site111Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site145Zn2+ 2 (UniProtKB | ChEBI)
Binding site175Zn2+ 2 (UniProtKB | ChEBI)
Binding site227Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site228dihydroxyacetone phosphate (UniProtKB | ChEBI)
Binding site265Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site266-268dihydroxyacetone phosphate (UniProtKB | ChEBI)
Binding site287-290dihydroxyacetone phosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionfructose-bisphosphate aldolase activity
Molecular Functionzinc ion binding
Biological Processglycolytic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Fructose-bisphosphate aldolase
  • EC number
  • Short names
    FBP aldolase

Gene names

    • ORF names
      EDF73_11941

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • BIGb0138
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Klebsiella/Raoultella group > Raoultella

Accessions

  • Primary accession
    A0A4R3ZCB8

Proteomes

Family & Domains

Sequence similarities

Belongs to the class II fructose-bisphosphate aldolase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    359
  • Mass (Da)
    39,156
  • Last updated
    2019-07-31 v1
  • Checksum
    A85663466F6F92A1
MSKIFDFVKPGVITGDDVQKVFQVAKENNFALPAVNCVGTDSINAVLEAAAKAKAPVIVQFSNGGAAFIAGKGVKTDVPQGAAILGAISGAHHVHQMAEHYGVPVILHTDHCAKKLLPWIDGLLDAGEKHYAATGKPLFSSHMIDLSEESLHENIEICSKYLARMAKLDMTLEIELGCTGGEEDGVDNSHMDASALYTQPEDVDYAYTELSKISPRFTIAASFGNVHGVYKPGNVVLTPTILRDSQEYVSKKHNLPHNSLNFVFHGGSGSSAQEIKDSVSYGVIKMNIDTDTQWATWDGILQYYKTNEAYLQGQLGNPKGEDQPNKKYYDPRVWLRAAQTSMVTRLEQAFKELNAVDVL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
SMCV01000019
EMBL· GenBank· DDBJ
TCW04591.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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