A0A4R2RY53 · A0A4R2RY53_9FIRM
- ProteinTranscription-repair-coupling factor
- Genemfd
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1221 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | damaged DNA binding | |
Molecular Function | DNA helicase activity | |
Molecular Function | hydrolase activity | |
Biological Process | regulation of DNA-templated transcription | |
Biological Process | transcription-coupled nucleotide-excision repair, DNA damage recognition |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTranscription-repair-coupling factor
- EC number
- Short namesTRCF
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Bacillota > Clostridia > Eubacteriales > Heliobacteriaceae > Heliophilum
Accessions
- Primary accessionA0A4R2RY53
Proteomes
Subcellular Location
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 648-809 | Helicase ATP-binding | ||||
Sequence: DMEKPKPMDRLLCGDVGYGKTEVAIRAAFKAVYEGFQVAILVPTTILAQQHYNTFRERFTGYAVTVEVLSRFRSAKEQKVTLEKLAKGSLDIVIGTHRLVSQDVRFKNLGLLIIDEEQRFGVAHKEKIKQLKQDVDVLTLSATPIPRTLHMSMVGLRDMSTI | ||||||
Domain | 818-984 | Helicase C-terminal | ||||
Sequence: PVQTYVVEHNPELIREAIKRELGRGGQVYYVRNRVEDLDRIARDLAKMVPDVRIGIGHGKMREDQLEQVMLDFIEGEYDILVCTTIIETGLDVPNVNTLIVDGADLMGLAQLYQLRGRVGRANRLAYAYFTYRKDKLLTEVAEKRLHAIREFTELGSGFKIAMRDLE | ||||||
Region | 1176-1221 | Disordered | ||||
Sequence: VAGGAPQDSQTTEPQTPPQPLLLQGAPAPRAKPMPASGMRPEVPRS | ||||||
Compositional bias | 1179-1194 | Polar residues | ||||
Sequence: GAPQDSQTTEPQTPPQ |
Sequence similarities
In the C-terminal section; belongs to the helicase family. RecG subfamily.
In the N-terminal section; belongs to the UvrB family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,221
- Mass (Da)136,254
- Last updated2019-07-31 v1
- Checksum0DC667F5F7213BE5
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1179-1194 | Polar residues | ||||
Sequence: GAPQDSQTTEPQTPPQ |
Keywords
- Technical term