A0A4R2B8U8 · A0A4R2B8U8_9BACI
- ProteinHomoserine O-acetyltransferase
- GenemetAA
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids302 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.
Catalytic activity
- L-homoserine + acetyl-CoA = O-acetyl-L-homoserine + CoA
Pathway
Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; O-acetyl-L-homoserine from L-homoserine: step 1/1.
Features
Showing features for site, active site, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 111 | Important for acyl-CoA specificity | ||||
Sequence: E | ||||||
Active site | 142 | Acyl-thioester intermediate | ||||
Sequence: C | ||||||
Binding site | 163 | substrate | ||||
Sequence: K | ||||||
Binding site | 192 | substrate | ||||
Sequence: S | ||||||
Site | 192 | Important for substrate specificity | ||||
Sequence: S | ||||||
Active site | 235 | Proton acceptor | ||||
Sequence: H | ||||||
Active site | 237 | |||||
Sequence: E | ||||||
Binding site | 249 | substrate | ||||
Sequence: R |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | homoserine O-acetyltransferase activity | |
Molecular Function | homoserine O-succinyltransferase activity | |
Biological Process | L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHomoserine O-acetyltransferase
- EC number
- Short namesHAT
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Bacillota > Bacilli > Bacillales > Bacillaceae > Mesobacillus
Accessions
- Primary accessionA0A4R2B8U8
Proteomes
Subcellular Location
Structure
Sequence
- Sequence statusComplete
- Length302
- Mass (Da)35,342
- Last updated2019-07-31 v1
- Checksum01F04B88D1D8FA89
Keywords
- Technical term