A0A4Q4NMP3 · MFS54_ALTAL

Function

function

MFS-type efflux pump involved in the modulation susceptibility to various compounds including the xenobiotics 2,3,5-triiodobenzoic acid (TIBA) and 2-chloro-5-hydroxypyridine (CHP), CuCl2 several fungicides (clotrimazole, fludioxonil, vinclozolin, and iprodione), potassium superoxide KO2, and the singlet oxygen-generating compound hematoporphyrin.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane
Molecular Functiontransmembrane transporter activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    MFS-type transporter MFS54

Gene names

    • Name
      MFS54
    • ORF names
      AA0117_g3624

Organism names

Accessions

  • Primary accession
    A0A4Q4NMP3

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane42-62Helical
Transmembrane78-98Helical
Transmembrane114-134Helical
Transmembrane139-159Helical
Transmembrane169-189Helical
Transmembrane197-217Helical
Transmembrane237-257Helical
Transmembrane265-285Helical
Transmembrane310-330Helical
Transmembrane343-363Helical
Transmembrane370-390Helical
Transmembrane400-420Helical
Transmembrane430-450Helical
Transmembrane507-527Helical

Keywords

Phenotypes & Variants

Disruption phenotype

Leads to a decreased production of conidia and a reduced radial growth by about 20% on potato dextrose agar plates (PubMed:30279684).
Leads also to increased sensitivity to the xenobiotics 2,3,5-triiodobenzoic acid (TIBA) and 2-chloro-5-hydroxypyridine (CHP), CuCl2 and several fungicides including clotrimazole, fludioxonil, vinclozolin, and iprodione (PubMed:30279684).
Increases also the sensitivity to potassium superoxide KO2 and the singlet oxygen-generating compound hematoporphyrin (PubMed:30279684).
Does not affect the sensitivity to H2O2, singlet oxygen-generating compounds rose Bengal and eosin Y, or to the cell wall disturbing compound Congo red (PubMed:30279684).

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004527531-538MFS-type transporter MFS54

Expression

Induction

Expression is down-regulated in the presence of TIBA or CHP, and induced in the presence of H2O2, clotrimazole, or vinclozolin (PubMed:30279684).
Expression is regulated by the stress-responsive transcription regulator Yap1 but not the Hog1 MAP kinase (PubMed:30279684).

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-22Disordered

Sequence similarities

Belongs to the major facilitator superfamily.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    538
  • Mass (Da)
    57,832
  • Last updated
    2019-07-31 v1
  • Checksum
    DB0C920D9C6234E1
MKEGVVTPPDSEKDLQNVEGSLNTEEEKAEEAHIQLSKGRFVLVLVGLVLAIFLASLDFTIISTAIPKITDEFHSLQDIGWYGSAFFITTAATTAHWGRLYTFFPLKWTYLTSIFFFELGSVICGAAPSSTALIIGRAICGIGAAGLFSGSYTIIAVLVPSADRPKYSGLMGASYGLASVVGPLIGGAFTSHVSWRWCFYINLPVGGVSCLFILLFFANEPPKSRPDWRGMLRQLDMLGLVLIVGAITCFILALQWGGVSKAWDSGAVIGTLVAFVVCMILFVIEQWWLGENAMVHSVMIKRRTIWVGSMFSFLINSAFLVTFYYLPIYFQSVQGVSASTSGVRTVPFILAVTFCVVIVGQIITKTGYAFPWMIVGAAITTIGSGMIYTFDTHSPAGKWIGYQILCGIGVGVSFQVPVMLIQATTKDADVPLATATLLFIQTLGGAFGVSSAQAAFQNTLLKQLAITAPGLNPQIVLDAGASELKRVIPEQFLQGVLEAYVSGFRECLIVGIAFGGAAFLAAFGFRFTNIKRTAAAEA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
PDXD01000005
EMBL· GenBank· DDBJ
RYN79724.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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