A0A4Q4NMP3 · MFS54_ALTAL
- ProteinMFS-type transporter MFS54
- GeneMFS54
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids538 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
MFS-type efflux pump involved in the modulation susceptibility to various compounds including the xenobiotics 2,3,5-triiodobenzoic acid (TIBA) and 2-chloro-5-hydroxypyridine (CHP), CuCl2 several fungicides (clotrimazole, fludioxonil, vinclozolin, and iprodione), potassium superoxide KO2, and the singlet oxygen-generating compound hematoporphyrin.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | transmembrane transporter activity |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameMFS-type transporter MFS54
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Dothideomycetes > Pleosporomycetidae > Pleosporales > Pleosporineae > Pleosporaceae > Alternaria > Alternaria sect. Alternaria > Alternaria alternata complex
Accessions
- Primary accessionA0A4Q4NMP3
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 42-62 | Helical | ||||
Sequence: VLVLVGLVLAIFLASLDFTII | ||||||
Transmembrane | 78-98 | Helical | ||||
Sequence: DIGWYGSAFFITTAATTAHWG | ||||||
Transmembrane | 114-134 | Helical | ||||
Sequence: IFFFELGSVICGAAPSSTALI | ||||||
Transmembrane | 139-159 | Helical | ||||
Sequence: ICGIGAAGLFSGSYTIIAVLV | ||||||
Transmembrane | 169-189 | Helical | ||||
Sequence: GLMGASYGLASVVGPLIGGAF | ||||||
Transmembrane | 197-217 | Helical | ||||
Sequence: WCFYINLPVGGVSCLFILLFF | ||||||
Transmembrane | 237-257 | Helical | ||||
Sequence: MLGLVLIVGAITCFILALQWG | ||||||
Transmembrane | 265-285 | Helical | ||||
Sequence: SGAVIGTLVAFVVCMILFVIE | ||||||
Transmembrane | 310-330 | Helical | ||||
Sequence: MFSFLINSAFLVTFYYLPIYF | ||||||
Transmembrane | 343-363 | Helical | ||||
Sequence: VRTVPFILAVTFCVVIVGQII | ||||||
Transmembrane | 370-390 | Helical | ||||
Sequence: FPWMIVGAAITTIGSGMIYTF | ||||||
Transmembrane | 400-420 | Helical | ||||
Sequence: IGYQILCGIGVGVSFQVPVML | ||||||
Transmembrane | 430-450 | Helical | ||||
Sequence: VPLATATLLFIQTLGGAFGVS | ||||||
Transmembrane | 507-527 | Helical | ||||
Sequence: CLIVGIAFGGAAFLAAFGFRF |
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Leads to a decreased production of conidia and a reduced radial growth by about 20% on potato dextrose agar plates (PubMed:30279684).
Leads also to increased sensitivity to the xenobiotics 2,3,5-triiodobenzoic acid (TIBA) and 2-chloro-5-hydroxypyridine (CHP), CuCl2 and several fungicides including clotrimazole, fludioxonil, vinclozolin, and iprodione (PubMed:30279684).
Increases also the sensitivity to potassium superoxide KO2 and the singlet oxygen-generating compound hematoporphyrin (PubMed:30279684).
Does not affect the sensitivity to H2O2, singlet oxygen-generating compounds rose Bengal and eosin Y, or to the cell wall disturbing compound Congo red (PubMed:30279684).
Leads also to increased sensitivity to the xenobiotics 2,3,5-triiodobenzoic acid (TIBA) and 2-chloro-5-hydroxypyridine (CHP), CuCl2 and several fungicides including clotrimazole, fludioxonil, vinclozolin, and iprodione (PubMed:30279684).
Increases also the sensitivity to potassium superoxide KO2 and the singlet oxygen-generating compound hematoporphyrin (PubMed:30279684).
Does not affect the sensitivity to H2O2, singlet oxygen-generating compounds rose Bengal and eosin Y, or to the cell wall disturbing compound Congo red (PubMed:30279684).
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000452753 | 1-538 | MFS-type transporter MFS54 | |||
Sequence: MKEGVVTPPDSEKDLQNVEGSLNTEEEKAEEAHIQLSKGRFVLVLVGLVLAIFLASLDFTIISTAIPKITDEFHSLQDIGWYGSAFFITTAATTAHWGRLYTFFPLKWTYLTSIFFFELGSVICGAAPSSTALIIGRAICGIGAAGLFSGSYTIIAVLVPSADRPKYSGLMGASYGLASVVGPLIGGAFTSHVSWRWCFYINLPVGGVSCLFILLFFANEPPKSRPDWRGMLRQLDMLGLVLIVGAITCFILALQWGGVSKAWDSGAVIGTLVAFVVCMILFVIEQWWLGENAMVHSVMIKRRTIWVGSMFSFLINSAFLVTFYYLPIYFQSVQGVSASTSGVRTVPFILAVTFCVVIVGQIITKTGYAFPWMIVGAAITTIGSGMIYTFDTHSPAGKWIGYQILCGIGVGVSFQVPVMLIQATTKDADVPLATATLLFIQTLGGAFGVSSAQAAFQNTLLKQLAITAPGLNPQIVLDAGASELKRVIPEQFLQGVLEAYVSGFRECLIVGIAFGGAAFLAAFGFRFTNIKRTAAAEA |
Structure
Sequence
- Sequence statusComplete
- Length538
- Mass (Da)57,832
- Last updated2019-07-31 v1
- ChecksumDB0C920D9C6234E1