A0A4P8YFT9 · A0A4P8YFT9_9ENTR
- ProteinProtein translocase subunit SecY
- GenesecY
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids443 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cell envelope Sec protein transport complex | |
Cellular Component | plasma membrane | |
Molecular Function | protein transmembrane transporter activity | |
Molecular Function | signal sequence binding | |
Biological Process | protein transport by the Sec complex | |
Biological Process | SRP-dependent cotranslational protein targeting to membrane, translocation |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameProtein translocase subunit SecY
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Jejubacter
Accessions
- Primary accessionA0A4P8YFT9
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 23-44 | Helical | ||||
Sequence: LLFVIGALIVFRIGSFIPIPGI | ||||||
Transmembrane | 75-98 | Helical | ||||
Sequence: ASIFALGIMPYISASIIIQLLTVV | ||||||
Transmembrane | 119-139 | Helical | ||||
Sequence: YTRYGTLVLAIFQSVGIATGL | ||||||
Transmembrane | 154-174 | Helical | ||||
Sequence: FAFYFTAVVSLVTGTMFLMWL | ||||||
Transmembrane | 186-203 | Helical | ||||
Sequence: GISIIIFAGIVAGLPPAI | ||||||
Transmembrane | 215-237 | Helical | ||||
Sequence: LHFLLLLLVAVLVFAVTFFVVFV | ||||||
Transmembrane | 274-296 | Helical | ||||
Sequence: VIPAIFASSIILFPATIASWFGG | ||||||
Transmembrane | 316-337 | Helical | ||||
Sequence: LYVLLYASAIIFFCFFYTALVF | ||||||
Transmembrane | 373-391 | Helical | ||||
Sequence: LTLVGALYITFICLIPEFM | ||||||
Transmembrane | 397-418 | Helical | ||||
Sequence: VPFYFGGTSLLIVVVVIMDFMA |
Keywords
- Cellular component
Interaction
Subunit
Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
Structure
Sequence
- Sequence statusComplete
- Length443
- Mass (Da)48,452
- Last updated2019-07-31 v1
- Checksum4E9C0273CF81A41D
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP040428 EMBL· GenBank· DDBJ | QCT18733.1 EMBL· GenBank· DDBJ | Genomic DNA |