A0A4D6QHV0 · A0A4D6QHV0_9TELE
- ProteinCytochrome c oxidase subunit 1
- GeneCOI
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids219 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Catalytic activity
- 4 Fe(II)-[cytochrome c] + 8 H+(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H+(out) + 2 H2OThis reaction proceeds in the forward direction.
4 RHEA-COMP:10350 + 8 H+ (in)CHEBI:15378+ CHEBI:15379 = 4 RHEA-COMP:14399 + 4 H+ (out)CHEBI:15378+ 2 CHEBI:15377
Cofactor
Protein has several cofactor binding sites:
Pathway
Energy metabolism; oxidative phosphorylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial respiratory chain complex IV | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | electron transport coupled proton transport | |
Biological Process | mitochondrial electron transport, cytochrome c to oxygen |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 1
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Characiformes > Characoidei > Alestidae > Brycinus
Accessions
- Primary accessionA0A4D6QHV0
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 6-25 | Helical | ||||
Sequence: FGAWAGMVGTALSLLIRAEL | ||||||
Transmembrane | 37-59 | Helical | ||||
Sequence: IYNVIVTAHAFVMIFFMVMPIMI | ||||||
Transmembrane | 93-113 | Helical | ||||
Sequence: FLLLLASSGVEAGAGTGWTVY | ||||||
Transmembrane | 133-155 | Helical | ||||
Sequence: SLHLAGISSILGAINFITTIINM | ||||||
Transmembrane | 167-194 | Helical | ||||
Sequence: LFVWAVLVTAVLLLLSLPVLAAGITMLL |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-219 | Cytochrome oxidase subunit I profile | ||||
Sequence: TLYLVFGAWAGMVGTALSLLIRAELSQPGSLLGDDQIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSGVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGISSILGAINFITTIINMKPPAISQYQTPLFVWAVLVTAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLF |
Sequence similarities
Belongs to the heme-copper respiratory oxidase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length219
- Mass (Da)23,354
- Last updated2019-07-03 v1
- ChecksumDB3524AF452796BF
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: T | ||||||
Non-terminal residue | 219 | |||||
Sequence: F |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
MK592942 EMBL· GenBank· DDBJ | QCF47227.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK592943 EMBL· GenBank· DDBJ | QCF47228.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK592946 EMBL· GenBank· DDBJ | QCF47231.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK592951 EMBL· GenBank· DDBJ | QCF47236.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK592952 EMBL· GenBank· DDBJ | QCF47237.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK592965 EMBL· GenBank· DDBJ | QCF47250.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK592966 EMBL· GenBank· DDBJ | QCF47251.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK592967 EMBL· GenBank· DDBJ | QCF47252.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK592968 EMBL· GenBank· DDBJ | QCF47253.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK592969 EMBL· GenBank· DDBJ | QCF47254.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK592970 EMBL· GenBank· DDBJ | QCF47255.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK592971 EMBL· GenBank· DDBJ | QCF47256.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK592972 EMBL· GenBank· DDBJ | QCF47257.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK592973 EMBL· GenBank· DDBJ | QCF47258.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK592974 EMBL· GenBank· DDBJ | QCF47259.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK592976 EMBL· GenBank· DDBJ | QCF47261.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK592977 EMBL· GenBank· DDBJ | QCF47262.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK592978 EMBL· GenBank· DDBJ | QCF47263.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK592979 EMBL· GenBank· DDBJ | QCF47264.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK592980 EMBL· GenBank· DDBJ | QCF47265.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK592981 EMBL· GenBank· DDBJ | QCF47266.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK592982 EMBL· GenBank· DDBJ | QCF47267.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK592983 EMBL· GenBank· DDBJ | QCF47268.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK592984 EMBL· GenBank· DDBJ | QCF47269.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK592985 EMBL· GenBank· DDBJ | QCF47270.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK592986 EMBL· GenBank· DDBJ | QCF47271.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK592987 EMBL· GenBank· DDBJ | QCF47272.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK592988 EMBL· GenBank· DDBJ | QCF47273.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK592989 EMBL· GenBank· DDBJ | QCF47274.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK592990 EMBL· GenBank· DDBJ | QCF47275.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK592991 EMBL· GenBank· DDBJ | QCF47276.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK592992 EMBL· GenBank· DDBJ | QCF47277.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK592993 EMBL· GenBank· DDBJ | QCF47278.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK592994 EMBL· GenBank· DDBJ | QCF47279.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK593018 EMBL· GenBank· DDBJ | QCF47303.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK593019 EMBL· GenBank· DDBJ | QCF47304.1 EMBL· GenBank· DDBJ | Genomic DNA |