A0A4D6QHV0 · A0A4D6QHV0_9TELE

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Cu cation (UniProtKB | Rhea| CHEBI:23378 )

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial respiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Strains
    • AMCC-211317
    • AMCC-211318
    • AMCC-211320
    • AMCC-211321
    • AMCC-211326
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Characiformes > Characoidei > Alestidae > Brycinus

Accessions

  • Primary accession
    A0A4D6QHV0

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane6-25Helical
Transmembrane37-59Helical
Transmembrane93-113Helical
Transmembrane133-155Helical
Transmembrane167-194Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-219Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    219
  • Mass (Da)
    23,354
  • Last updated
    2019-07-03 v1
  • Checksum
    DB3524AF452796BF
TLYLVFGAWAGMVGTALSLLIRAELSQPGSLLGDDQIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSGVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGISSILGAINFITTIINMKPPAISQYQTPLFVWAVLVTAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLF

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue219

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MK592942
EMBL· GenBank· DDBJ
QCF47227.1
EMBL· GenBank· DDBJ
Genomic DNA
MK592943
EMBL· GenBank· DDBJ
QCF47228.1
EMBL· GenBank· DDBJ
Genomic DNA
MK592946
EMBL· GenBank· DDBJ
QCF47231.1
EMBL· GenBank· DDBJ
Genomic DNA
MK592951
EMBL· GenBank· DDBJ
QCF47236.1
EMBL· GenBank· DDBJ
Genomic DNA
MK592952
EMBL· GenBank· DDBJ
QCF47237.1
EMBL· GenBank· DDBJ
Genomic DNA
MK592965
EMBL· GenBank· DDBJ
QCF47250.1
EMBL· GenBank· DDBJ
Genomic DNA
MK592966
EMBL· GenBank· DDBJ
QCF47251.1
EMBL· GenBank· DDBJ
Genomic DNA
MK592967
EMBL· GenBank· DDBJ
QCF47252.1
EMBL· GenBank· DDBJ
Genomic DNA
MK592968
EMBL· GenBank· DDBJ
QCF47253.1
EMBL· GenBank· DDBJ
Genomic DNA
MK592969
EMBL· GenBank· DDBJ
QCF47254.1
EMBL· GenBank· DDBJ
Genomic DNA
MK592970
EMBL· GenBank· DDBJ
QCF47255.1
EMBL· GenBank· DDBJ
Genomic DNA
MK592971
EMBL· GenBank· DDBJ
QCF47256.1
EMBL· GenBank· DDBJ
Genomic DNA
MK592972
EMBL· GenBank· DDBJ
QCF47257.1
EMBL· GenBank· DDBJ
Genomic DNA
MK592973
EMBL· GenBank· DDBJ
QCF47258.1
EMBL· GenBank· DDBJ
Genomic DNA
MK592974
EMBL· GenBank· DDBJ
QCF47259.1
EMBL· GenBank· DDBJ
Genomic DNA
MK592976
EMBL· GenBank· DDBJ
QCF47261.1
EMBL· GenBank· DDBJ
Genomic DNA
MK592977
EMBL· GenBank· DDBJ
QCF47262.1
EMBL· GenBank· DDBJ
Genomic DNA
MK592978
EMBL· GenBank· DDBJ
QCF47263.1
EMBL· GenBank· DDBJ
Genomic DNA
MK592979
EMBL· GenBank· DDBJ
QCF47264.1
EMBL· GenBank· DDBJ
Genomic DNA
MK592980
EMBL· GenBank· DDBJ
QCF47265.1
EMBL· GenBank· DDBJ
Genomic DNA
MK592981
EMBL· GenBank· DDBJ
QCF47266.1
EMBL· GenBank· DDBJ
Genomic DNA
MK592982
EMBL· GenBank· DDBJ
QCF47267.1
EMBL· GenBank· DDBJ
Genomic DNA
MK592983
EMBL· GenBank· DDBJ
QCF47268.1
EMBL· GenBank· DDBJ
Genomic DNA
MK592984
EMBL· GenBank· DDBJ
QCF47269.1
EMBL· GenBank· DDBJ
Genomic DNA
MK592985
EMBL· GenBank· DDBJ
QCF47270.1
EMBL· GenBank· DDBJ
Genomic DNA
MK592986
EMBL· GenBank· DDBJ
QCF47271.1
EMBL· GenBank· DDBJ
Genomic DNA
MK592987
EMBL· GenBank· DDBJ
QCF47272.1
EMBL· GenBank· DDBJ
Genomic DNA
MK592988
EMBL· GenBank· DDBJ
QCF47273.1
EMBL· GenBank· DDBJ
Genomic DNA
MK592989
EMBL· GenBank· DDBJ
QCF47274.1
EMBL· GenBank· DDBJ
Genomic DNA
MK592990
EMBL· GenBank· DDBJ
QCF47275.1
EMBL· GenBank· DDBJ
Genomic DNA
MK592991
EMBL· GenBank· DDBJ
QCF47276.1
EMBL· GenBank· DDBJ
Genomic DNA
MK592992
EMBL· GenBank· DDBJ
QCF47277.1
EMBL· GenBank· DDBJ
Genomic DNA
MK592993
EMBL· GenBank· DDBJ
QCF47278.1
EMBL· GenBank· DDBJ
Genomic DNA
MK592994
EMBL· GenBank· DDBJ
QCF47279.1
EMBL· GenBank· DDBJ
Genomic DNA
MK593018
EMBL· GenBank· DDBJ
QCF47303.1
EMBL· GenBank· DDBJ
Genomic DNA
MK593019
EMBL· GenBank· DDBJ
QCF47304.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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