A0A430QWB0 · A0A430QWB0_THESC
- Protein3-oxoacyl-[acyl-carrier-protein] synthase 2
- GenefabF
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids408 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.
Catalytic activity
- (9Z)-hexadecenoyl-[ACP] + H+ + malonyl-[ACP] = 3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]
- a fatty acyl-[ACP] + H+ + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]
Pathway
Lipid metabolism; fatty acid biosynthesis.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 161 | For beta-ketoacyl synthase activity | ||||
Sequence: C |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 3-oxoacyl-[acyl-carrier-protein] synthase activity | |
Biological Process | fatty acid biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name3-oxoacyl-[acyl-carrier-protein] synthase 2
- EC number
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Deinococcota > Deinococci > Thermales > Thermaceae > Thermus
Accessions
- Primary accessionA0A430QWB0
Proteomes
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-407 | Ketosynthase family 3 (KS3) | ||||
Sequence: MRRVVVTGLGPLTPIGVGAEAYHKAQLAGKSGVRPIARFDASALPVRIAAEVDVNPEEFIDKKELRRLDRFVQYALIAAELALKDAGLEPSALDPERVGTLVGTGIGGMETWEAQSKVFLERGPNRISPFFIPMMIANMASAHIAMRYGFMGPSSTAVTACATGSDAIGNALRMIQLGEADVVLAGGTEAAITPMAIGAFAVMRALSTRNEEPTKASRPFTLSRDGFVMGEGAGVLVLEEYEHAKRRGARIYAELVGFGRSADAHHITEPHPEGKGAALAMRRALLDAKVNPEEVGYINAHGTSTPVGDRAEVLAIKEVFKEHAQRLMVSSTKSMTGHLLGAAGGIEAIATVQALYHGVIPPTINLEDPDPELDLDFVPEPREAKVAYALSNSFAFGGQNAVLLFKR |
Sequence similarities
Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length408
- Mass (Da)43,446
- Last updated2019-05-08 v1
- Checksum34474764B934712E
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
PELP01000581 EMBL· GenBank· DDBJ | RTG99349.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
PELM01000099 EMBL· GenBank· DDBJ | RTH03865.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
PEMD01000313 EMBL· GenBank· DDBJ | RTH29802.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
PELZ01000022 EMBL· GenBank· DDBJ | RTH39936.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
PEMW01000444 EMBL· GenBank· DDBJ | RTI49190.1 EMBL· GenBank· DDBJ | Genomic DNA |