A0A423PQV4 · A0A423PQV4_9GAMM

  • Protein
    Formate-dependent phosphoribosylglycinamide formyltransferase
  • Gene
    purT
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide from N1-(5-phospho-D-ribosyl)glycinamide (formate route): step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site22-23N1-(5-phospho-beta-D-ribosyl)glycinamide (UniProtKB | ChEBI)
Binding site82N1-(5-phospho-beta-D-ribosyl)glycinamide (UniProtKB | ChEBI)
Binding site114ATP (UniProtKB | ChEBI)
Binding site155ATP (UniProtKB | ChEBI)
Binding site160-165ATP (UniProtKB | ChEBI)
Binding site198-201ATP (UniProtKB | ChEBI)
Binding site206ATP (UniProtKB | ChEBI)
Binding site270Mg2+ (UniProtKB | ChEBI)
Binding site282Mg2+ (UniProtKB | ChEBI)
Binding site289N1-(5-phospho-beta-D-ribosyl)glycinamide (UniProtKB | ChEBI)
Binding site359N1-(5-phospho-beta-D-ribosyl)glycinamide (UniProtKB | ChEBI)
Binding site366-367N1-(5-phospho-beta-D-ribosyl)glycinamide (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionATP binding
Molecular Functionligase activity
Molecular Functionmagnesium ion binding
Molecular Functionphosphoribosylglycinamide formyltransferase 2 activity
Molecular Functionphosphoribosylglycinamide formyltransferase activity
Biological Process'de novo' IMP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Formate-dependent phosphoribosylglycinamide formyltransferase
  • EC number
  • Alternative names
    • 5'-phosphoribosylglycinamide transformylase 2
    • Formate-dependent GAR transformylase
    • GAR transformylase 2
      (GART 2
      )
    • Non-folate glycinamide ribonucleotide transformylase
    • Phosphoribosylglycinamide formyltransferase 2

Gene names

    • Name
      purT
    • ORF names
      SAOR_06675

Organism names

  • Taxonomic identifier
  • Strain
    • MK-B5
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Salinisphaerales > Salinisphaeraceae > Salinisphaera

Accessions

  • Primary accession
    A0A423PQV4

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain119-311ATP-grasp

Sequence similarities

Belongs to the PurK/PurT family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    396
  • Mass (Da)
    42,649
  • Last updated
    2019-05-08 v1
  • Checksum
    6C0667EF3CFF5DCC
MHAIGTPCSDTATRVMLLGAGELGREIAIELQRLGCEVIAVDRYASAPAMAVAHRWQVLEMNDPAALRAVVEAEAPALIVPEIEAIATEALIELEAEGHRVVPTARATRLTMDREGIRRLAADELGLPTSPFRFAETEADYRAAIEAIGLPCVVKPVMSSSGKGQSTLREAADIDAAWRHSQSGGRGRRGAGTRIIVEGFVEFDYEITLLTVVHAGGTSFCAPIGHRQVDGDYRESWQPQPMSDAARAEAERQAGAITAALGGRGLFGVELFVAGDRVWFSEVSPRPHDTGLVTLASQDLSEFALHARAILELPIPTIRQYGPSASAVILGDGESDRLRYAGLDHALAAPQTYLHLFGKPVIHGKRRLGVALARGENLDEARDRARSCANKVRIEY

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AYKH01000011
EMBL· GenBank· DDBJ
ROO27989.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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