A0A401HQ12 · A0A401HQ12_9EURY
- ProteinPhosphoribosylaminoimidazole-succinocarboxamide synthase
- GenepurC
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids242 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
Catalytic activity
- 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H+ + phosphate
Pathway
Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | ATP binding | |
Molecular Function | phosphoribosylaminoimidazolesuccinocarboxamide synthase activity | |
Biological Process | 'de novo' IMP biosynthetic process | |
Biological Process | cobalamin biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphoribosylaminoimidazole-succinocarboxamide synthase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageArchaea > Euryarchaeota > Methanomada group > Methanococci > Methanococcales > Methanofervidicoccus
Accessions
- Primary accessionA0A401HQ12
Proteomes
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 14-238 | SAICAR synthetase/ADE2 N-terminal | ||||
Sequence: LYSGKVKSIYEIDEDSVLIEFRDDITAGDGKKRDVKKGKGHLNALISSKLFEVLNKEDIPTHYLGYIDPVYMVAKKVEIIPIEVIVRNIAAGSLCKRYPFKEGEELKRPIVQFDYKSDEYGDPMLNEDIAIALGLATEEELKKLRELALRVNDTLKRFFDEKGIILVDFKIEIGRTKDGHLVVADEISPDTMRLWDKETKDVLDKDVFRKDLGDVVSKYEIVAKR |
Sequence similarities
Belongs to the SAICAR synthetase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length242
- Mass (Da)27,721
- Last updated2019-05-08 v1
- ChecksumEE19A2003790C9B1
Keywords
- Technical term