A0A3U8MFA7 · A0A3U8MFA7_SALET
- Proteinsite-specific DNA-methyltransferase (adenine-specific)
- GenehsdM
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids529 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
Catalytic activity
- a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N6-methyl-2'-deoxyadenosine in DNA + H+ + S-adenosyl-L-homocysteine
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Molecular Function | DNA binding | |
Molecular Function | hydrolase activity | |
Molecular Function | N-methyltransferase activity | |
Molecular Function | site-specific DNA-methyltransferase (adenine-specific) activity | |
Biological Process | DNA restriction-modification system | |
Biological Process | methylation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended namesite-specific DNA-methyltransferase (adenine-specific)
- EC number
Gene names
Organism names
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Salmonella
Accessions
- Primary accessionA0A3U8MFA7
Proteomes
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 6-108 | N6 adenine-specific DNA methyltransferase N-terminal | ||||
Sequence: LVAKLWKLCDNLRDGGVSYQNYVNELASLLFLKMCKETGQEADYLPEGYRWDDLKSRIGQDQMQFYRNLLVQLGSDEKKLVQAVFHNVSTTIEQPKQLTELVS | ||||||
Domain | 123-449 | DNA methylase adenine-specific | ||||
Sequence: SRDDFGDMYEGLLQKNANETKSGAGQYFTPRPLIKTIIHLLKPQPREVVQDPAAGTAGFLIEADRYVKSQTNDLDDLDGDTQDFQIHRAFIGLELVPGTRRLALMNCLLHDIEGNLDHGGAIRLGNTLGSDGENLPKAHIVATNPPFGSAAGTNITRTFVHPTSNKQLCFMQHIIETLHPGGRAAVVVPDNVLFEGGKGTDIRRDLMDKCHLHTILRLPTGIFYAQGVKTNVLFFTKGTVTNPHQDKNCTDDVWVYDLRTNMPSFGKRTPFTEQHLQPFETVYGEDPHGLSPREEGEWSFNAEESEVADSEENKNTDQHQATSRWRK | ||||||
Region | 405-444 | Disordered | ||||
Sequence: YGEDPHGLSPREEGEWSFNAEESEVADSEENKNTDQHQAT | ||||||
Compositional bias | 429-444 | Basic and acidic residues | ||||
Sequence: VADSEENKNTDQHQAT |
Sequence similarities
Belongs to the N(4)/N(6)-methyltransferase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length529
- Mass (Da)59,311
- Last updated2019-07-31 v1
- ChecksumD5EF542069B8A88A
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 429-444 | Basic and acidic residues | ||||
Sequence: VADSEENKNTDQHQAT |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AAGQRK010000026 EMBL· GenBank· DDBJ | EBQ9557509.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAGUJO010000008 EMBL· GenBank· DDBJ | EBS0961775.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAHEUI010000012 EMBL· GenBank· DDBJ | EBV2986939.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAHFXK010000004 EMBL· GenBank· DDBJ | EBV6519561.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAHGQK010000038 EMBL· GenBank· DDBJ | EBV8815112.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAHISP010000007 EMBL· GenBank· DDBJ | EBW5681214.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAHKMO010000003 EMBL· GenBank· DDBJ | EBX1942756.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAHPBO010000027 EMBL· GenBank· DDBJ | EBY7953519.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAHXFC010000007 EMBL· GenBank· DDBJ | ECB3240368.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAKMXF010000003 EMBL· GenBank· DDBJ | ECT4760959.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAKNFH010000002 EMBL· GenBank· DDBJ | ECT5777801.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAKNOB010000051 EMBL· GenBank· DDBJ | ECT6848416.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAKTHQ010000002 EMBL· GenBank· DDBJ | ECV3903568.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAKRVI010000004 EMBL· GenBank· DDBJ | ECV5645385.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAKRVM010000002 EMBL· GenBank· DDBJ | ECV5659944.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAAFWJ010000004 EMBL· GenBank· DDBJ | HAB1780325.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAAFXT010000003 EMBL· GenBank· DDBJ | HAB1946332.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAAHDR010000003 EMBL· GenBank· DDBJ | HAB5604564.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAAMIP010000002 EMBL· GenBank· DDBJ | HAC6796101.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAAQRT010000002 EMBL· GenBank· DDBJ | HAE0605045.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAARAI010000003 EMBL· GenBank· DDBJ | HAE1599460.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAARBR010000009 EMBL· GenBank· DDBJ | HAE1766286.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAARCT010000032 EMBL· GenBank· DDBJ | HAE1895767.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAARVP010000002 EMBL· GenBank· DDBJ | HAE4128977.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAASAE010000021 EMBL· GenBank· DDBJ | HAE4669253.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAASLC010000051 EMBL· GenBank· DDBJ | HAE5988850.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAASMN010000013 EMBL· GenBank· DDBJ | HAE6095027.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAASMF010000012 EMBL· GenBank· DDBJ | HAE6127228.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAASYE010000006 EMBL· GenBank· DDBJ | HAE7539122.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAATGC010000007 EMBL· GenBank· DDBJ | HAE8246549.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAATGU010000002 EMBL· GenBank· DDBJ | HAE8326798.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAATVI010000008 EMBL· GenBank· DDBJ | HAF0271693.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAAWGN010000017 EMBL· GenBank· DDBJ | HAF7796416.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAAWIW010000008 EMBL· GenBank· DDBJ | HAF8073988.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP040700 EMBL· GenBank· DDBJ | QCW63102.1 EMBL· GenBank· DDBJ | Genomic DNA |