A0A3R7RRV3 · A0A3R7RRV3_9BACT

  • Protein
    Sulfite reductase [NADPH] hemoprotein beta-component
  • Gene
    cysI
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster per subunit.
siroheme (UniProtKB | Rhea| CHEBI:60052 )

Note: Binds 1 siroheme per subunit.

Pathway

Sulfur metabolism; hydrogen sulfide biosynthesis; hydrogen sulfide from sulfite (NADPH route): step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site434[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site440[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site479[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site483[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site483Fe (UniProtKB | ChEBI) of siroheme (UniProtKB | ChEBI); axial binding residue

GO annotations

AspectTerm
Cellular Componentsulfite reductase complex (NADPH)
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functionheme binding
Molecular Functionmetal ion binding
Molecular FunctionNADP binding
Molecular Functionsulfite reductase (ferredoxin) activity
Molecular Functionsulfite reductase (NADPH) activity
Biological Processcysteine biosynthetic process
Biological Processhydrogen sulfide biosynthetic process
Biological Processsulfate assimilation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Sulfite reductase [NADPH] hemoprotein beta-component
  • EC number
  • Short names
    SiR-HP
    ; SiRHP

Gene names

    • Name
      cysI
    • ORF names
      CBD67_002455

Organism names

Accessions

  • Primary accession
    A0A3R7RRV3

Proteomes

Subcellular Location

Interaction

Subunit

Alpha8-beta8. The alpha component is a flavoprotein, the beta component is a hemoprotein.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain71-130Nitrite/Sulfite reductase ferredoxin-like
Domain173-328Nitrite/sulphite reductase 4Fe-4S
Domain351-415Nitrite/Sulfite reductase ferredoxin-like

Sequence similarities

Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    582
  • Mass (Da)
    65,269
  • Last updated
    2019-04-10 v1
  • Checksum
    E47AA103D3BBBBEE
MISDSQSPEKLHKNESIKSASEFLRGTILEGLSESVTGSISAEDQQLTKFHGIYQQDNRDNRAERRRKKLDKAYTFMARICLPGGICTPEQWIAVNDLANFCEFDTLKITTRQALQLHGILKSNLKNTIRTVNDALLTTLAACGDVNRNVMSNPNPPESRVFTEVQAIAEAVDTHLKPRTSAYAEIWLDGEKVVSHGDSEIEPLYGKTYLPRKFKIAFAIPPHNDVDVFAHCLGFIAIIKDDQLLGFNVTVGGGMGMTHGNEETFPRLADVIAFCTPDQVIDVSEKIVSIQRDFGDRTNRAHARFKYTLEDRGKDAILQELETRLGYKLEAPKAYKFESNSDRYGWVQDFEGLWNVGLYIEGGRVLDNDKLKIKTGLKEIAKIHKGDFRLTANQNIIIGRIADKDKAEIQALIEEYGLDGYEKFSGIRKNQISCVALPTCGLALAESERYLPTLVTEIEGLLEELGLYNEPIIIRSTGCPNGCGRPYLGEIGLVGKVPGKYNLYLGAGFDGERLNKLYKNSVTHEQIIECLKPIFIDYAKNRQANERFGDFTIRSGYVNATNHGNAFHSDLKEIQYQEKVQQ

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
NHJE02000008
EMBL· GenBank· DDBJ
RPG15157.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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