A0A3N2PTD5 · A0A3N2PTD5_9PEZI

Function

function

Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Pathway

Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site32-35IMP (UniProtKB | ChEBI)
Binding site34Mg2+ (UniProtKB | ChEBI)
Binding site34-36GTP (UniProtKB | ChEBI)
Active site35Proton donor
Binding site123IMP (UniProtKB | ChEBI)
Active site134
Binding site137IMP (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site215IMP (UniProtKB | ChEBI)
Binding site230IMP (UniProtKB | ChEBI)
Binding site290-296substrate
Binding site294IMP (UniProtKB | ChEBI)
Binding site296GTP (UniProtKB | ChEBI)
Binding site332-334GTP (UniProtKB | ChEBI)
Binding site416-418GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionadenylosuccinate synthase activity
Molecular FunctionGTP binding
Molecular Functionmagnesium ion binding
Biological Process'de novo' AMP biosynthetic process
Biological ProcessIMP metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Adenylosuccinate synthetase
  • EC number
  • Short names
    AMPSase
    ; AdSS
  • Alternative names
    • IMP--aspartate ligase

Gene names

    • ORF names
      SODALDRAFT_334805

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • F11
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Hypocreomycetidae > Glomerellales > Plectosphaerellaceae > Sodiomyces

Accessions

  • Primary accession
    A0A3N2PTD5

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the adenylosuccinate synthetase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    429
  • Mass (Da)
    47,372
  • Last updated
    2019-02-13 v1
  • Checksum
    1DECE69931234503
MATIILGSQWGKLTDILAPKAQLCARAAGGHNAGHSIVANGISYSFHLLPSGLMTENLNLIGSGVVFHVPSFFKELDELEKKGLKGVHDRIFVSDRVHVDLDLHVAVDGLEEVELGASKIGTTCRGIGPSYSTKAARSGIRLSEVFNAELFEAKIRRLASSFQKRYGDLLKYDVEEEIARFNEYRPKLAKYTVDAVAFIKQAQDKNMKILVEGANALMLDIDYGTYPYVTSSNTGLGGIFTGLAINPTKIDEIIGVVKAYTTRVGGGPFVTEDTEEAGTKLQEIGREWGVSTGRKRRCGCTSILYFVSAQMIVMLIIHLQAINHYTALNLTKLDVLDTFPTIKVAVAYKDPDTGEEIPSFPADLSQLERVEVVYQELPGWNQPTAKIQTFMDLPVQARDYVHFIENFVGVKIKWIGTGPDREDMIYRTS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
ML119057
EMBL· GenBank· DDBJ
ROT37684.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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