A0A3N0AHQ1 · A0A3N0AHQ1_9ACTN

  • Protein
    Glyceraldehyde-3-phosphate dehydrogenase
  • Gene
    gap
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.

Features

Showing features for binding site, active site, site.

TypeIDPosition(s)Description
Binding site12-13NAD+ (UniProtKB | ChEBI)
Binding site34NAD+ (UniProtKB | ChEBI)
Binding site78NAD+ (UniProtKB | ChEBI)
Binding site120NAD+ (UniProtKB | ChEBI)
Binding site151-153D-glyceraldehyde 3-phosphate (UniProtKB | ChEBI)
Active site152Nucleophile
Site179Activates thiol group during catalysis
Binding site182D-glyceraldehyde 3-phosphate (UniProtKB | ChEBI)
Binding site210-211D-glyceraldehyde 3-phosphate (UniProtKB | ChEBI)
Binding site233D-glyceraldehyde 3-phosphate (UniProtKB | ChEBI)
Binding site317NAD+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionglyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Molecular FunctionNAD binding
Molecular FunctionNADP binding
Biological Processglucose metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Glyceraldehyde-3-phosphate dehydrogenase
  • EC number

Gene names

    • Name
      gap
    • ORF names
      DMP07_01785

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • DSM 17537
  • Taxonomic lineage
    Bacteria > Actinomycetota > Coriobacteriia > Eggerthellales > Eggerthellaceae > Slackia

Accessions

  • Primary accession
    A0A3N0AHQ1

Proteomes

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain3-152Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding

Sequence similarities

Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    333
  • Mass (Da)
    36,329
  • Last updated
    2019-02-13 v1
  • Checksum
    B9DC47932054ACE0
MAIKVGINGFGRIGRLVYRAMANDPELDVVAVNDLGDIPTMAHLLKYDSVHGRAFDKVEVVEDGFIADGHKTKVLCEREPSNLPWGELGVDVVVESTGIFKTGELASKHIEAGAKKVIISCPAKGEDITIVMGVNDGDYDKEKHHIISNASCTTNCLAPFAKVLMENFGIKRGYMNTIHAYTNDQKILDLPHKDLRRARAAALSMIPTTTGAARAVSLVLPELKGKLDGFATRVPTPDGSMVDLTVQLEREVTKEEINAAMKAAAEGPLKGILEYTEDPIVSIDIVGNSHSSIFDSQLTMVMGEKSDMVKCISWYDNEWGYSNRVKDLAKILL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QICB01000001
EMBL· GenBank· DDBJ
RNL21585.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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