A0A3M7BFV9 · A0A3M7BFV9_HORWE
- ProteinmRNA cap guanine-N7 methyltransferase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids338 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Responsible for methylating the 5'-cap structure of mRNAs.
Catalytic activity
- a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N7-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity | |
Molecular Function | RNA binding |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namemRNA cap guanine-N7 methyltransferase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Dothideomycetes > Dothideomycetidae > Mycosphaerellales > Teratosphaeriaceae > Hortaea
Accessions
- Primary accessionA0A3M7BFV9
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-111 | Disordered | ||||
Sequence: MAGDDLPSNVTAPRPIQKRKRPQDNAARANKSARTSTPNAYARRTPPPEPKPIDPEQEDNDGDQSPPRKLKRPGAGARVAREQRQAAEAVRHRREEDQRRQAQEERQRSGA | ||||||
Compositional bias | 28-42 | Polar residues | ||||
Sequence: RANKSARTSTPNAYA | ||||||
Compositional bias | 49-68 | Basic and acidic residues | ||||
Sequence: EPKPIDPEQEDNDGDQSPPR | ||||||
Compositional bias | 84-111 | Basic and acidic residues | ||||
Sequence: RQAAEAVRHRREEDQRRQAQEERQRSGA | ||||||
Domain | 133-338 | MRNA cap 0 methyltransferase | ||||
Sequence: SQIKGLRNLNNWIKSTLIQKFARPETIPQHGYLVLDMACGKGGDLGKWSKASPPPGLYVGCDIADVSIEQARGRWAETRRKVMDAEFYVQDTFGRPLFEVPIVRQVGFNPNCGPGNGIIQGGMPTGGFDVVSMMFALHYSFEREDLARGMLKNVAGALKKGGRFIGCMPNSDVISATVKRSLQAEAPGTTPARKSATPARTAEADA | ||||||
Region | 315-338 | Disordered | ||||
Sequence: QAEAPGTTPARKSATPARTAEADA |
Sequence similarities
In the N-terminal section; belongs to the dsDNA virus mRNA guanylyltransferase family.
Family and domain databases
Sequence
- Sequence statusFragment
- Length338
- Mass (Da)37,213
- Last updated2019-02-13 v1
- Checksum612A6F070320C7C4
Features
Showing features for compositional bias, non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 28-42 | Polar residues | ||||
Sequence: RANKSARTSTPNAYA | ||||||
Compositional bias | 49-68 | Basic and acidic residues | ||||
Sequence: EPKPIDPEQEDNDGDQSPPR | ||||||
Compositional bias | 84-111 | Basic and acidic residues | ||||
Sequence: RQAAEAVRHRREEDQRRQAQEERQRSGA | ||||||
Non-terminal residue | 338 | |||||
Sequence: A |