A0A3G8QV21 · A0A3G8QV21_9EURY

  • Protein
    6,7-dimethyl-8-ribityllumazine synthase
  • Gene
    ribH
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Pathway

Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site115-amino-6-(D-ribitylamino)uracil (UniProtKB | ChEBI)
Binding site43-455-amino-6-(D-ribitylamino)uracil (UniProtKB | ChEBI)
Binding site67-695-amino-6-(D-ribitylamino)uracil (UniProtKB | ChEBI)
Binding site72-73(2S)-2-hydroxy-3-oxobutyl phosphate (UniProtKB | ChEBI)
Active site75Proton donor
Binding site1005-amino-6-(D-ribitylamino)uracil (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentriboflavin synthase complex
Molecular Function6,7-dimethyl-8-ribityllumazine synthase activity
Biological Processriboflavin biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    6,7-dimethyl-8-ribityllumazine synthase
  • EC number
  • Short names
    DMRL synthase
    ; LS
    ; Lumazine synthase

Gene names

    • Name
      ribH
    • ORF names
      ATH50_0406
      , DU502_09480

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • CGMCC 1.10124
    • JCM 16430
  • Taxonomic lineage
    Archaea > Euryarchaeota > Stenosarchaea group > Halobacteria > Halobacteriales > Haloferacaceae > Haloplanus

Accessions

  • Primary accession
    A0A3G8QV21

Proteomes

Subcellular Location

Family & Domains

Sequence similarities

Belongs to the DMRL synthase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    134
  • Mass (Da)
    13,704
  • Last updated
    2019-02-13 v1
  • Checksum
    1252E355C7307375
MVTLGLVVAQFNASVTEPMAEEARAAAAEADADIAETVEVPGSYDAPLAADRLARRDDIDAVAVVGAIVTGDTAHDRVIGDATAQALTQVSLDRDTPVTFGVSGPGMSGAEARERVEKGAEAVNAAVEMVRTLP

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP034145
EMBL· GenBank· DDBJ
AZH25598.1
EMBL· GenBank· DDBJ
Genomic DNA
REFS01000001
EMBL· GenBank· DDBJ
RMB25320.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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