A0A3G8QV21 · A0A3G8QV21_9EURY
- Protein6,7-dimethyl-8-ribityllumazine synthase
- GeneribH
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids134 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
Catalytic activity
- (2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O + H+
Pathway
Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 11 | 5-amino-6-(D-ribitylamino)uracil (UniProtKB | ChEBI) | ||||
Sequence: F | ||||||
Binding site | 43-45 | 5-amino-6-(D-ribitylamino)uracil (UniProtKB | ChEBI) | ||||
Sequence: SYD | ||||||
Binding site | 67-69 | 5-amino-6-(D-ribitylamino)uracil (UniProtKB | ChEBI) | ||||
Sequence: AIV | ||||||
Binding site | 72-73 | (2S)-2-hydroxy-3-oxobutyl phosphate (UniProtKB | ChEBI) | ||||
Sequence: DT | ||||||
Active site | 75 | Proton donor | ||||
Sequence: H | ||||||
Binding site | 100 | 5-amino-6-(D-ribitylamino)uracil (UniProtKB | ChEBI) | ||||
Sequence: F |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | riboflavin synthase complex | |
Molecular Function | 6,7-dimethyl-8-ribityllumazine synthase activity | |
Biological Process | riboflavin biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name6,7-dimethyl-8-ribityllumazine synthase
- EC number
- Short namesDMRL synthase ; LS ; Lumazine synthase
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageArchaea > Euryarchaeota > Stenosarchaea group > Halobacteria > Halobacteriales > Haloferacaceae > Haloplanus
Accessions
- Primary accessionA0A3G8QV21
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Sequence
- Sequence statusComplete
- Length134
- Mass (Da)13,704
- Last updated2019-02-13 v1
- Checksum1252E355C7307375
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP034145 EMBL· GenBank· DDBJ | AZH25598.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
REFS01000001 EMBL· GenBank· DDBJ | RMB25320.1 EMBL· GenBank· DDBJ | Genomic DNA |