A0A3B4BCE7 · A0A3B4BCE7_9GOBI
- ProteinVoltage-gated inwardly rectifying potassium channel KCNH2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1056 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- K+(in) = K+(out)
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | monoatomic ion channel complex | |
Molecular Function | inward rectifier potassium channel activity | |
Biological Process | membrane repolarization during action potential | |
Biological Process | regulation of heart rate by cardiac conduction | |
Biological Process | regulation of ventricular cardiac muscle cell membrane repolarization |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameVoltage-gated inwardly rectifying potassium channel KCNH2
- Alternative names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Gobiaria > Gobiiformes > Gobioidei > Gobiidae > Oxudercinae > Periophthalmus
Accessions
- Primary accessionA0A3B4BCE7
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 381-402 | Helical | ||||
Sequence: WLILLLVIYTAILTPYSAAFLL | ||||||
Transmembrane | 517-541 | Helical | ||||
Sequence: AAVLFLLMCTFALIAHWLACIWYAI | ||||||
Transmembrane | 603-627 | Helical | ||||
Sequence: IFSICVMLIGSLMYASIFGNVSAII |
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Interaction
Subunit
The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Interacts with DNAJB12 and DNAJB14; chaperones DNAJB12 and DNAJB14 promote tetramerization. Heteromultimer with KCNH6/ERG2 and KCNH7/ERG3. Interacts with ALG10B. Forms a stable complex with KCNE1 or KCNE2, and that this heteromultimerization regulates Inward rectifier potassium channel activity. Interacts with CANX. The core-glycosylated, but not the fully glycosylated form interacts with RNF207. Interacts with NDFIP1 and NDFIP2; this interaction decreases the cell membrane expression by targeting KCNH2, through interaction with NEDD4L, for the degradation through the multivesicular bodies (MVBs)-lysosomal pathway.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 92-144 | PAC | ||||
Sequence: RKVEIDLYRKDGECFLCMVDVVPVKNEDGVVIMFILNFEVMSEDSLIDGRSEL | ||||||
Domain | 706-806 | Cyclic nucleotide-binding | ||||
Sequence: AFKGSTKGCLRALAMKFKTTHAPPGDTLVHAGDVLTALYFISRGSIEILRGDVVVAILGKNDIFGEPINLYSRPGKSNADVRALTYCDLHKILREDIMEVL | ||||||
Region | 1018-1056 | Disordered | ||||
Sequence: PGACVSMDPESQRRLSLQEPQTPLDSRTPQRHRSDPGGS | ||||||
Compositional bias | 1028-1042 | Polar residues | ||||
Sequence: SQRRLSLQEPQTPLD |
Sequence similarities
Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.1/KCNH2 sub-subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,056
- Mass (Da)118,880
- Last updated2018-12-05 v1
- Checksum36762B1E4DBF8EB8
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1028-1042 | Polar residues | ||||
Sequence: SQRRLSLQEPQTPLD |