A0A3B4BCE7 · A0A3B4BCE7_9GOBI

  • Protein
    Voltage-gated inwardly rectifying potassium channel KCNH2
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmonoatomic ion channel complex
Molecular Functioninward rectifier potassium channel activity
Biological Processmembrane repolarization during action potential
Biological Processregulation of heart rate by cardiac conduction
Biological Processregulation of ventricular cardiac muscle cell membrane repolarization

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Voltage-gated inwardly rectifying potassium channel KCNH2
  • Alternative names
    • Ether-a-go-go-related gene potassium channel 1
    • Potassium voltage-gated channel subfamily H member 2
    • Voltage-gated potassium channel subunit Kv11.1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Gobiaria > Gobiiformes > Gobioidei > Gobiidae > Oxudercinae > Periophthalmus

Accessions

  • Primary accession
    A0A3B4BCE7

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane381-402Helical
Transmembrane517-541Helical
Transmembrane603-627Helical

Keywords

PTM/Processing

Keywords

Interaction

Subunit

The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Interacts with DNAJB12 and DNAJB14; chaperones DNAJB12 and DNAJB14 promote tetramerization. Heteromultimer with KCNH6/ERG2 and KCNH7/ERG3. Interacts with ALG10B. Forms a stable complex with KCNE1 or KCNE2, and that this heteromultimerization regulates Inward rectifier potassium channel activity. Interacts with CANX. The core-glycosylated, but not the fully glycosylated form interacts with RNF207. Interacts with NDFIP1 and NDFIP2; this interaction decreases the cell membrane expression by targeting KCNH2, through interaction with NEDD4L, for the degradation through the multivesicular bodies (MVBs)-lysosomal pathway.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain92-144PAC
Domain706-806Cyclic nucleotide-binding
Region1018-1056Disordered
Compositional bias1028-1042Polar residues

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,056
  • Mass (Da)
    118,880
  • Last updated
    2018-12-05 v1
  • Checksum
    36762B1E4DBF8EB8
MPVRRGHVAPQNTFLDTIIRKFDSQSRKFVIANARVENCAIIFCNDGFCHMCGYSRGEIMQKPCTCNFLYGPGTKRLAIAQMAQALLGSEERKVEIDLYRKDGECFLCMVDVVPVKNEDGVVIMFILNFEVMSEDSLIDGRSELNHRLPTWFVTGRPRGFKLRLPLLRSLSNSKMSLNDAEVGHIPTATPLPLHPEPCHESLGLGEFLPLPPLPSSPCVAPHHHRLSLNPDASGSNCSLSHSRSRESFHSMRRASSVDEIEAMRPDWDRKNRRASAVNSKSNILNSTSDSDLMRYRAISKIPQITLNFVDFKPDPLITLPTGEMDIIAPCKLIDRTHHVTEKVTQVLSLGADVLPEYKLQAPRIHKWTVLHYSPFKAVWDWLILLLVIYTAILTPYSAAFLLNDQEEQIMQSCGYSCSPLNVVDLIVDIMFIIDILINFRTTYVNSNDEVVSHPIKIAVHYFKGWFLIDMVAAIPFDLLIYRNGEETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGSVERNGSIGWLHTLGDQLGKHYNGSGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRTLLQNCKAFKGSTKGCLRALAMKFKTTHAPPGDTLVHAGDVLTALYFISRGSIEILRGDVVVAILGKNDIFGEPINLYSRPGKSNADVRALTYCDLHKILREDIMEVLDMYPEFADHFWNNLEITFNLRDTNMIPGSPSSDESKSGGFNKLRRRKLSFRRRTEKGISAEGKWDLLLEYCSNEYLGLIQLPVLIRAFSGVSNIFSFWGESRGGGQYQEVPSCSLASPPPLHTPVHSLSRQQRSQLDARLDLLQKQLNRLESRMSADIGAIMQLLQRQMALVPPAYSAVSSPPQVRWPSQDSVNLLIYCELHQVSGGMELTPGACVSMDPESQRRLSLQEPQTPLDSRTPQRHRSDPGGS

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1028-1042Polar residues

Genome annotation databases

Similar Proteins

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