A0A3A9AX23 · A0A3A9AX23_UNCXX
- ProteinADP-dependent (S)-NAD(P)H-hydrate dehydratase
- GenennrD
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids298 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
Catalytic activity
- (6S)-NADHX + ADP = AMP + H+ + NADH + phosphate
Cofactor
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 42 | (6S)-NADPHX (UniProtKB | ChEBI) | ||||
Sequence: A | ||||||
Binding site | 106 | (6S)-NADPHX (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 163 | (6S)-NADPHX (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 199-203 | AMP (UniProtKB | ChEBI) | ||||
Sequence: KGPVS | ||||||
Binding site | 227 | AMP (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 228 | (6S)-NADPHX (UniProtKB | ChEBI) | ||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | ADP-dependent NAD(P)H-hydrate dehydratase activity | |
Molecular Function | ATP binding | |
Molecular Function | NADHX epimerase activity | |
Molecular Function | NADPHX epimerase activity | |
Biological Process | metabolite repair | |
Biological Process | nicotinamide nucleotide metabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameADP-dependent (S)-NAD(P)H-hydrate dehydratase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria
Accessions
- Primary accessionA0A3A9AX23
Proteomes
Interaction
Subunit
Homotetramer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 7-287 | YjeF C-terminal | ||||
Sequence: SNDELAKLLPFPAADANKYTRGRLIAMVGSAAYPGAACLSARAAERMGAGYVEVVTDEEAFLPIHLASSSLVVRSWSRFKAATWPALRLGHPVAYLVGSGFDSADETSVQRTRQVLKRAKAPVVVDGGGLDALVAEKTARIVAQRVEDGFDTVITPHMGEAARLAKPLGISTEDPAQLSLDLARAYQVVVLLKGPVSYISDGKKAIAMDKGSSVLAKAGTGDVLAGMVSALLAQGLSACDACILAATLHAYAGSIAAKCIGEIGVIASDVIGAIGPAIDEL |
Sequence similarities
Belongs to the NnrD/CARKD family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length298
- Mass (Da)30,865
- Last updated2018-12-05 v1
- ChecksumB6EC300277D3A236
Keywords
- Technical term