A0A3A9AX23 · A0A3A9AX23_UNCXX

  • Protein
    ADP-dependent (S)-NAD(P)H-hydrate dehydratase
  • Gene
    nnrD
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site42(6S)-NADPHX (UniProtKB | ChEBI)
Binding site106(6S)-NADPHX (UniProtKB | ChEBI)
Binding site163(6S)-NADPHX (UniProtKB | ChEBI)
Binding site199-203AMP (UniProtKB | ChEBI)
Binding site227AMP (UniProtKB | ChEBI)
Binding site228(6S)-NADPHX (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular FunctionADP-dependent NAD(P)H-hydrate dehydratase activity
Molecular FunctionATP binding
Molecular FunctionNADHX epimerase activity
Molecular FunctionNADPHX epimerase activity
Biological Processmetabolite repair
Biological Processnicotinamide nucleotide metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ADP-dependent (S)-NAD(P)H-hydrate dehydratase
  • EC number
  • Alternative names
    • ADP-dependent NAD(P)HX dehydratase

Gene names

    • Name
      nnrD
    • ORF names
      D7W09_05005

Organism names

Accessions

  • Primary accession
    A0A3A9AX23

Proteomes

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain7-287YjeF C-terminal

Sequence similarities

Belongs to the NnrD/CARKD family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    298
  • Mass (Da)
    30,865
  • Last updated
    2018-12-05 v1
  • Checksum
    B6EC300277D3A236
MELTRFSNDELAKLLPFPAADANKYTRGRLIAMVGSAAYPGAACLSARAAERMGAGYVEVVTDEEAFLPIHLASSSLVVRSWSRFKAATWPALRLGHPVAYLVGSGFDSADETSVQRTRQVLKRAKAPVVVDGGGLDALVAEKTARIVAQRVEDGFDTVITPHMGEAARLAKPLGISTEDPAQLSLDLARAYQVVVLLKGPVSYISDGKKAIAMDKGSSVLAKAGTGDVLAGMVSALLAQGLSACDACILAATLHAYAGSIAAKCIGEIGVIASDVIGAIGPAIDELDNVESACNQAL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
RAZB01000004
EMBL· GenBank· DDBJ
RKI95992.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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