A0A3A8JFG4 · A0A3A8JFG4_9BACT

Function

function

Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Pathway

Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 1/4.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site65-69GTP (UniProtKB | ChEBI)
Binding site70Zn2+ (UniProtKB | ChEBI); catalytic
Binding site81Zn2+ (UniProtKB | ChEBI); catalytic
Binding site83Zn2+ (UniProtKB | ChEBI); catalytic
Binding site86GTP (UniProtKB | ChEBI)
Binding site108-110GTP (UniProtKB | ChEBI)
Binding site130GTP (UniProtKB | ChEBI)
Active site142Proton acceptor
Active site144Nucleophile
Binding site165GTP (UniProtKB | ChEBI)
Binding site170GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionGTP binding
Molecular FunctionGTP cyclohydrolase II activity
Molecular Functionzinc ion binding
Biological Processriboflavin biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    GTP cyclohydrolase-2
  • EC number
  • Alternative names
    • GTP cyclohydrolase II

Gene names

    • Name
      ribA
    • ORF names
      D7W82_03545

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • CA049B
  • Taxonomic lineage
    Bacteria > Myxococcota > Myxococcia > Myxococcales > Cystobacterineae > Myxococcaceae > Corallococcus

Accessions

  • Primary accession
    A0A3A8JFG4

Proteomes

Subcellular Location

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region1-24Disordered
Domain21-186GTP cyclohydrolase II

Sequence similarities

Belongs to the GTP cyclohydrolase II family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    224
  • Mass (Da)
    25,005
  • Last updated
    2018-12-05 v1
  • Checksum
    9CCA1D3FE49DD4E5
MSDTRSPQVLPTRKPTQHLERYSEADVPTARGVLKTIVFRDKRNGKEHVALVVGEPQGLEGVPVRIHSECLTSEVFGSLKCDCREQLDRALDFVSQNGLGVVLYLRQEGRGIGLGNKIKAYALQSKGLDTYEANRQLGFADDLRSYDIAAEMLRSLDVRSVDLITNNPLKIAGLVEEGVAVRRRIPSRTEHNPHNVDYLKTKRERTGHLIELFAEDDDTEAKAG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
RAWC01000009
EMBL· GenBank· DDBJ
RKG90600.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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