A0A3A8JFG4 · A0A3A8JFG4_9BACT
- ProteinGTP cyclohydrolase-2
- GeneribA
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids224 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
Catalytic activity
- GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 2 phosphate + 3 H+
Cofactor
Note: Binds 1 zinc ion per subunit.
Pathway
Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 1/4.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 65-69 | GTP (UniProtKB | ChEBI) | ||||
Sequence: RIHSE | ||||||
Binding site | 70 | Zn2+ (UniProtKB | ChEBI); catalytic | ||||
Sequence: C | ||||||
Binding site | 81 | Zn2+ (UniProtKB | ChEBI); catalytic | ||||
Sequence: C | ||||||
Binding site | 83 | Zn2+ (UniProtKB | ChEBI); catalytic | ||||
Sequence: C | ||||||
Binding site | 86 | GTP (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 108-110 | GTP (UniProtKB | ChEBI) | ||||
Sequence: EGR | ||||||
Binding site | 130 | GTP (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Active site | 142 | Proton acceptor | ||||
Sequence: D | ||||||
Active site | 144 | Nucleophile | ||||
Sequence: R | ||||||
Binding site | 165 | GTP (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 170 | GTP (UniProtKB | ChEBI) | ||||
Sequence: K |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | GTP binding | |
Molecular Function | GTP cyclohydrolase II activity | |
Molecular Function | zinc ion binding | |
Biological Process | riboflavin biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGTP cyclohydrolase-2
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Myxococcota > Myxococcia > Myxococcales > Cystobacterineae > Myxococcaceae > Corallococcus
Accessions
- Primary accessionA0A3A8JFG4
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-24 | Disordered | ||||
Sequence: MSDTRSPQVLPTRKPTQHLERYSE | ||||||
Domain | 21-186 | GTP cyclohydrolase II | ||||
Sequence: RYSEADVPTARGVLKTIVFRDKRNGKEHVALVVGEPQGLEGVPVRIHSECLTSEVFGSLKCDCREQLDRALDFVSQNGLGVVLYLRQEGRGIGLGNKIKAYALQSKGLDTYEANRQLGFADDLRSYDIAAEMLRSLDVRSVDLITNNPLKIAGLVEEGVAVRRRIP |
Sequence similarities
Belongs to the GTP cyclohydrolase II family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length224
- Mass (Da)25,005
- Last updated2018-12-05 v1
- Checksum9CCA1D3FE49DD4E5