A0A3A5ULA1 · A0A3A5ULA1_9ARCH
- ProteinTritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific)
- GeneuppS
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids259 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
Catalytic activity
- geranylgeranyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + tri-trans,hepta-cis-undecaprenyl diphosphate
Cofactor
Note: Binds 2 magnesium ions per subunit.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 38 | |||||
Sequence: D | ||||||
Binding site | 38 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 39-42 | substrate | ||||
Sequence: GNRR | ||||||
Binding site | 43 | substrate | ||||
Sequence: F | ||||||
Binding site | 55 | substrate | ||||
Sequence: H | ||||||
Binding site | 83-85 | substrate | ||||
Sequence: STE | ||||||
Active site | 86 | Proton acceptor | ||||
Sequence: N | ||||||
Binding site | 89 | substrate | ||||
Sequence: R | ||||||
Binding site | 208 | substrate | ||||
Sequence: R | ||||||
Binding site | 214-216 | substrate | ||||
Sequence: RIS | ||||||
Binding site | 227 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: E |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | magnesium ion binding | |
Molecular Function | polyprenyltransferase activity | |
Biological Process | polyprenol biosynthetic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific)
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageArchaea > Candidatus Thermoplasmatota > Candidatus Poseidoniia > Candidatus Poseidoniales
Accessions
- Primary accessionA0A3A5ULA1
Proteomes
Interaction
Subunit
Homodimer.
Structure
Sequence
- Sequence statusComplete
- Length259
- Mass (Da)30,051
- Last updated2018-12-05 v1
- ChecksumA64508A344F5D1CD