A0A379G8Q3 · A0A379G8Q3_9BACT

  • Protein
    4-diphosphocytidyl-2-C-methyl-D-erythritol kinase
  • Gene
    ispE
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

Catalytic activity

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6.

Features

Showing features for active site, binding site.

128120406080100120140160180200220240260280
TypeIDPosition(s)Description
Active site12
Binding site98-108ATP (UniProtKB | ChEBI)
Active site140

GO annotations

AspectTerm
Molecular Function4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity
Molecular FunctionATP binding
Biological Processisopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
Biological Processphosphorylation
Biological Processterpenoid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    4-diphosphocytidyl-2-C-methyl-D-erythritol kinase
  • EC number
  • Short names
    CMK
  • Alternative names
    • 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase

Gene names

    • Name
      ispE
    • ORF names
      NCTC13043_01886

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • NCTC13043
  • Taxonomic lineage
    Bacteria > Bacteroidota > Bacteroidia > Bacteroidales > Prevotellaceae > Prevotella

Accessions

  • Primary accession
    A0A379G8Q3

Proteomes

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain92-146GHMP kinase N-terminal
Domain214-263GHMP kinase C-terminal

Sequence similarities

Belongs to the GHMP kinase family. IspE subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    281
  • Mass (Da)
    30,811
  • Last updated
    2018-11-07 v1
  • Checksum
    46DA23F53A03958A
MEEKLIVYPNCKINLGLNVVRKRSDGYHDLETVFYPVPLCDKLEAVVGEGAEGTCSLAISGNKIEGELSDNLIVKAYRMLSADHILPHINFNLEKHIPSQAGLGGGSSDATYTLRLLNKLCQLNLNSATLHQYAVRLGADCAFFVTATPAFATGIGDILEPMNAECAHLHGMYLLIVKPTVAISTAQAFAFVKPEPTLIKCKDIVAQPVNSEWRNHLTNNFEVSAFKLHPEMHTIKEQLYNMGALYAQMSGSGSAFFGIFNTPPTLTANHFNGMFTYLCQL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
UGTP01000002
EMBL· GenBank· DDBJ
SUC37398.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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