A0A379AS82 · A0A379AS82_AVIAV

Function

function

Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide from N1-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.

Features

Showing features for binding site, active site, site.

TypeIDPosition(s)Description
Binding site90-93(6R)-10-formyltetrahydrofolate (UniProtKB | ChEBI)
Binding site107(6R)-10-formyltetrahydrofolate (UniProtKB | ChEBI)
Active site109Proton donor
Site145Raises pKa of active site His

GO annotations

AspectTerm
Molecular Functionphosphoribosylglycinamide formyltransferase activity
Biological Process'de novo' IMP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoribosylglycinamide formyltransferase
  • EC number
  • Alternative names
    • 5'-phosphoribosylglycinamide transformylase
    • GAR transformylase
      (GART
      )

Gene names

    • Name
      purN
    • ORF names
      NCTC11297_01180

Organism names

Accessions

  • Primary accession
    A0A379AS82

Proteomes

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain2-182Formyl transferase N-terminal

Sequence similarities

Belongs to the GART family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    212
  • Mass (Da)
    23,453
  • Last updated
    2018-11-07 v1
  • Checksum
    28ADA3F65B93F6FE
MKKIVVLISGEGQTLQSIIDACKAGDIPAQICAVIANKANAYGLQRAKMAEIPTALFERKDYADNLAMDQAIGDYIAELGADLIVLAGYMKILTAEFTQRFAGKILNIHPSLLPKYPGLHTYQRALEAGDQEHGTTVHFVNEEVDGGAIVLQAKVPIFPDDEVSDIEQRVKYQEQQIYPLVINWFVTERLRLKEGKAYLDQCALPENGYAAE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
UGSP01000001
EMBL· GenBank· DDBJ
SUB24151.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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