A0A378WHU0 · A0A378WHU0_9NEIS

  • Protein
    D-aminoacyl-tRNA deacylase
  • Gene
    dtd
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionD-aminoacyl-tRNA deacylase activity
Molecular FunctionGly-tRNA(Ala) hydrolase activity
Molecular FunctionSer(Gly)-tRNA(Ala) hydrolase activity
Molecular FunctiontRNA binding
Biological ProcessD-amino acid catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    D-aminoacyl-tRNA deacylase
  • EC number
  • Short names
    DTD
  • Alternative names
    • Gly-tRNA(Ala) deacylase
      (EC:3.1.1.-
      ) . EC:3.1.1.- (UniProtKB | ENZYME | Rhea)

Gene names

    • Name
      dtd
    • ORF names
      NCTC12229_01033

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • NCTC12229
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Betaproteobacteria > Neisseriales > Neisseriaceae > Neisseria

Accessions

  • Primary accession
    A0A378WHU0

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for motif.

TypeIDPosition(s)Description
Motif141-142Gly-cisPro motif, important for rejection of L-amino acids

Domain

A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.

Sequence similarities

Belongs to the DTD family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    153
  • Mass (Da)
    16,825
  • Last updated
    2018-11-07 v1
  • Checksum
    9D0D6A5DBE03C41A
MRAVIQKVTRAQVKVIEADRSDVTGAINHGFMVLLGVGEGDTEADAQYIADKIANLRIFEDDAGKLNQSLKDTGGAILLVSQFTLYADARNGRRPSFSNAAKPESANRLYEYVADLLRKHGITVETGRFQTHMQIDLCNDGPVTLLLDSKKLF

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
UGRS01000001
EMBL· GenBank· DDBJ
SUA36612.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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