A0A373LN00 · A0A373LN00_9FIRM

  • Protein
    NAD-dependent protein deacetylase
  • Gene
    cobB
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site24NAD+ (UniProtKB | ChEBI)
Binding site28NAD+ (UniProtKB | ChEBI)
Binding site35NAD+ (UniProtKB | ChEBI)
Binding site35nicotinamide (UniProtKB | ChEBI)
Binding site36NAD+ (UniProtKB | ChEBI)
Binding site103NAD+ (UniProtKB | ChEBI)
Binding site105NAD+ (UniProtKB | ChEBI)
Binding site105nicotinamide (UniProtKB | ChEBI)
Binding site106NAD+ (UniProtKB | ChEBI)
Binding site106nicotinamide (UniProtKB | ChEBI)
Active site121Proton acceptor
Binding site121NAD+ (UniProtKB | ChEBI)
Binding site129Zn2+ (UniProtKB | ChEBI)
Binding site132Zn2+ (UniProtKB | ChEBI)
Binding site150Zn2+ (UniProtKB | ChEBI)
Binding site152Zn2+ (UniProtKB | ChEBI)
Binding site190NAD+ (UniProtKB | ChEBI)
Binding site191NAD+ (UniProtKB | ChEBI)
Binding site213NAD+ (UniProtKB | ChEBI)
Binding site231NAD+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionNAD+ binding
Molecular FunctionNAD-dependent protein lysine deacetylase activity
Molecular Functiontransferase activity
Molecular Functionzinc ion binding

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NAD-dependent protein deacetylase
  • EC number
  • Alternative names
    • Regulatory protein SIR2 homolog

Gene names

    • Name
      cobB
    • ORF names
      DW006_04750

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • AF36-5BH
  • Taxonomic lineage
    Bacteria > Bacillota > Clostridia > Eubacteriales > Eubacteriaceae > Eubacterium

Accessions

  • Primary accession
    A0A373LN00

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-241Deacetylase sirtuin-type

Sequence similarities

Belongs to the sirtuin family. Class U subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    241
  • Mass (Da)
    26,882
  • Last updated
    2018-11-07 v1
  • Checksum
    4803BE7A188BA0B3
MEENIKKLKEIIDGSDNIVFFGGAGVSTESGVPDFRSVDGLYNQEYAYPPETILSHSFYRRNPEEFYRFYRNKMLFPSAEPNMAHKALAKLEEMGKLKAVITQNIDGLHQAAGSKNVYELHGSVHRNHCQDCGKFYGFDQVYEMEGIPRCQCGGIIKPDVVLYEEGLDQKTIQLSVEAIAKADVLIIGGTSLAVYPAAGLVDYYRGNKLVLINKSKTQKDQRADLVINQPIGEVLGQVVEL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QTVG01000004
EMBL· GenBank· DDBJ
RGF51447.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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