A0A349N0R4 · A0A349N0R4_9FIRM

  • Protein
    Signal recognition particle protein
  • Gene
    ffh
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site108-115GTP (UniProtKB | ChEBI)
Binding site190-194GTP (UniProtKB | ChEBI)
Binding site248-251GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentsignal recognition particle
Molecular Function7S RNA binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionGTP binding
Molecular FunctionGTPase activity
Biological ProcessSRP-dependent cotranslational protein targeting to membrane

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Signal recognition particle protein
  • EC number
  • Alternative names
    • Fifty-four homolog

Gene names

    • Name
      ffh
    • ORF names
      DCS74_02220

Organism names

Accessions

  • Primary accession
    A0A349N0R4

Proteomes

Subcellular Location

Cytoplasm
Note: The SRP-RNC complex is targeted to the cytoplasmic membrane.

Keywords

Interaction

Subunit

Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain2-87Signal recognition particle SRP54 helical bundle
Domain100-247AAA+ ATPase
Domain101-297SRP54-type proteins GTP-binding
Region431-450Disordered

Domain

Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.

Sequence similarities

Belongs to the GTP-binding SRP family. SRP54 subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    450
  • Mass (Da)
    49,671
  • Last updated
    2018-11-07 v1
  • Checksum
    753968557B1AF08F
MAFENLGDKLQNAFKDLRGRGKLSENDIDAALREVRRALLEADVNFKVAKDFIARVREKAMGEEVFGSLKPDQTVIKIVRDELTELLGGTQSRLTMSSSGMTVIMLVGLQGAGKTTTAGKLGLMLKKKGKHPLLAACDVYRPAAVRQLEVLGEQTGVPVYRMQEGADPVQIAKSAVDTARSYNKDVVILDTAGRLTIDEQLMEELRSIKGAVHPHEILLVLDSMTGQDAVTTAKAFDESLGIDGTILTKLDGDARGGAALSIKSVTGKPIKLIGVSEKLDGGLEEFHPDRMAGRILDLGDLETLIEQAQRNLDQDAMQETMERMKKGAFTLDDFLKQMRQIRRMGSFQSLLGLIPGMGKYKEQLKNVDLDGREMKHLEAIILSMTPQERCDPAVLNGSRRKRIAMGSGTHVQDVNRIIKQFMEMRKQMKKMKGMNPAKMKNAGFPGMFRK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DMZC01000057
EMBL· GenBank· DDBJ
HAT56378.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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