A0A346N337 · A0A346N337_9GAMM

  • Protein
    Beta-ketoacyl-[acyl-carrier-protein] synthase III
  • Gene
    fabH
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.

Pathway

Lipid metabolism; fatty acid biosynthesis.

Features

Showing features for active site.

133550100150200250300
TypeIDPosition(s)Description
Active site115
Active site262
Active site292

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function3-oxoacyl-[acyl-carrier-protein] synthase activity
Molecular Functionbeta-ketoacyl-acyl-carrier-protein synthase III activity
Biological Processfatty acid biosynthetic process
Biological Processsecondary metabolite biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Beta-ketoacyl-[acyl-carrier-protein] synthase III
  • EC number
  • Short names
    Beta-ketoacyl-ACP synthase III
    ; KAS III
  • Alternative names
    • 3-oxoacyl-[acyl-carrier-protein] synthase 3
    • 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene names

    • Name
      fabH
    • ORF names
      D0B54_15390

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • K1W22B-7
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Nevskiales > Nevskiaceae > Solimonas

Accessions

  • Primary accession
    A0A346N337

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain109-190Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Domain246-335Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Region263-267ACP-binding

Domain

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

Sequence similarities

Belongs to the thiolase-like superfamily. FabH family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    335
  • Mass (Da)
    36,300
  • Last updated
    2018-11-07 v1
  • Checksum
    23923EDE8B8B2FE2
MAAARARILGLGTYVPARTVTNHDLVKVMDTSHEWIVERSGIEERHWVEPEDGNYTMGVKAARAALADAGCEASEIDCIIYATLSPDYFFPGCGVLVQRELGIGHVPAFDIRQQCSGFVYGLQMADSFIRSGLYKKILLIGGEVHSRGLDKSTRGRTVTVLFGDAAGAAVIGASDDPARGILTSRMHSDGSDAECLAIQWPGMAAGRETFVTHEDIDEGRIFTTMDGQKVFKTAVKRMPEVIHEVLADQGLAVSDIDMLIPHQANLRINEMVAKLLHIDASKVHNNIQKYGNTTAATIPLCLAEARALGKVKRGDLVCAVAFGSGFTWGAVLMRW

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP031704
EMBL· GenBank· DDBJ
AXQ29974.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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