A0A318KZN4 · A0A318KZN4_9NEIS

Function

function

Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Features

Showing features for binding site.

1840100200300400500600700800
TypeIDPosition(s)Description
Binding site506-513ATP (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionDNA binding
Biological Processcell division

Keywords

Names & Taxonomy

Protein names

  • Submitted names
    • DNA translocase FtsK

Gene names

    • ORF names
      DFR34_101306

Organism names

  • Taxonomic identifier
  • Strain
    • DSM 29661
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Betaproteobacteria > Neisseriales > Aquaspirillaceae > Rivihabitans

Accessions

  • Primary accession
    A0A318KZN4

Proteomes

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane26-49Helical
Transmembrane79-101Helical
Transmembrane113-135Helical
Transmembrane141-160Helical
Transmembrane167-187Helical

Keywords

Interaction

Subunit

Homohexamer. Forms a ring that surrounds DNA.

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region224-274Disordered
Region286-367Disordered
Compositional bias350-364Pro residues
Domain489-696FtsK

Sequence similarities

Belongs to the FtsK/SpoIIIE/SftA family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    840
  • Mass (Da)
    89,886
  • Last updated
    2018-10-10 v1
  • Checksum
    69B1DFEC46091924
MSFLKKRKPAAVRNDAPALPPKLSRLLHLATGLALTLGVLLLVAALASYSPDDNAWSHSADLPYTHNWMGAPGAWLSDILLFVFGLSAWWLPLYAALMVWFGQRDDERFSPELLSWAGLAVYGGFTVLLLSSSAFEAIRLYSLDVALPLSAGGIVGDMLGKTLHRALGFNGASLLLMIAMLVGFSAFTHVSWLNLMEAIGAGVEYLALAVRRLWQRSLGEEMLDTPHAGSPASQAPAAEVASEPVADSPAEEAPAAPLASGSRIEPRLGDEPTLADEHPAQADIAAQADSPADHHAATASAASHEPPVLALDSEDEPTSATERDSPTAAMPEAQPSTVPAQVPRRHGPPRLLLPSAPLPPDTLLQRLPPDAATDEETVDKTRVEQALLALGVPATVLSAHVGPVVIRYEFEAGDAIAPERRATLARELTQALAVDSLRLLDSVPGKSCMALEHPRRQRQPILLSVALRSPAWRNSPSRLTLALGVDSSGQPMTADLARMPHVLLAGAPGSGKTTALHAMLLSLLYKATPEEARLLLIDPEHSLAAYRELPHLLAPVVSDMQQAALALGWCMSEMERRYQLMARLGVRNLASYNQKLREADSRDERIADPFSEPDDLKPLELMPAIVVVVNELAELMAQGGKQVEERLARLAQKARAAGIHLVLATGRASAEVITGLIKANIPTRMAFQVASKVDSRLILEQMGAETLLGQGDMLYKPPGSDYALRVHGADVSPADISQVTEFVRRTGKPDYVDGLLEGAPSVGLPRPHRVADPSEVALDPLYDDAVALVRQLDKATVMLLQNEFNIGATRAIRLLDSLELTGVISAADANGHRKVLAVSL

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias350-364Pro residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QJKI01000001
EMBL· GenBank· DDBJ
PXX82072.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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