A0A318KZN4 · A0A318KZN4_9NEIS
- ProteinDNA translocase FtsK
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids840 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif.
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | DNA binding | |
Biological Process | cell division |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Betaproteobacteria > Neisseriales > Aquaspirillaceae > Rivihabitans
Accessions
- Primary accessionA0A318KZN4
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 26-49 | Helical | ||||
Sequence: LLHLATGLALTLGVLLLVAALASY | ||||||
Transmembrane | 79-101 | Helical | ||||
Sequence: ILLFVFGLSAWWLPLYAALMVWF | ||||||
Transmembrane | 113-135 | Helical | ||||
Sequence: LLSWAGLAVYGGFTVLLLSSSAF | ||||||
Transmembrane | 141-160 | Helical | ||||
Sequence: YSLDVALPLSAGGIVGDMLG | ||||||
Transmembrane | 167-187 | Helical | ||||
Sequence: LGFNGASLLLMIAMLVGFSAF |
Keywords
- Cellular component
Interaction
Subunit
Homohexamer. Forms a ring that surrounds DNA.
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 224-274 | Disordered | ||||
Sequence: DTPHAGSPASQAPAAEVASEPVADSPAEEAPAAPLASGSRIEPRLGDEPTL | ||||||
Region | 286-367 | Disordered | ||||
Sequence: AQADSPADHHAATASAASHEPPVLALDSEDEPTSATERDSPTAAMPEAQPSTVPAQVPRRHGPPRLLLPSAPLPPDTLLQRL | ||||||
Compositional bias | 350-364 | Pro residues | ||||
Sequence: RLLLPSAPLPPDTLL | ||||||
Domain | 489-696 | FtsK | ||||
Sequence: GQPMTADLARMPHVLLAGAPGSGKTTALHAMLLSLLYKATPEEARLLLIDPEHSLAAYRELPHLLAPVVSDMQQAALALGWCMSEMERRYQLMARLGVRNLASYNQKLREADSRDERIADPFSEPDDLKPLELMPAIVVVVNELAELMAQGGKQVEERLARLAQKARAAGIHLVLATGRASAEVITGLIKANIPTRMAFQVASKVDSR |
Sequence similarities
Belongs to the FtsK/SpoIIIE/SftA family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length840
- Mass (Da)89,886
- Last updated2018-10-10 v1
- Checksum69B1DFEC46091924
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 350-364 | Pro residues | ||||
Sequence: RLLLPSAPLPPDTLL |