A0A318D3A7 · A0A318D3A7_9GAMM

  • Protein
    Protein translocase subunit SecA
  • Gene
    secA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • ATP + H2O + cellular proteinSide 1 = ADP + phosphate + cellular proteinSide 2.
    EC:7.4.2.8 (UniProtKB | ENZYME | Rhea)

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Features

Showing features for binding site.

1904100200300400500600700800900
TypeIDPosition(s)Description
Binding site85ATP (UniProtKB | ChEBI)
Binding site103-107ATP (UniProtKB | ChEBI)
Binding site510ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcell envelope Sec protein transport complex
Cellular Componentcytosol
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Biological Processintracellular protein transmembrane transport
Biological Processprotein import
Biological Processprotein targeting
Biological Processprotein transport by the Sec complex

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein translocase subunit SecA
  • EC number

Gene names

    • Name
      secA
    • ORF names
      DL796_07580

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • ATCC BAA-2076
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Kangiellales > Kangiellaceae > Kangiella

Accessions

  • Primary accession
    A0A318D3A7

Proteomes

Subcellular Location

Cell membrane
; Peripheral membrane protein
Cytoplasm
Membrane
; Peripheral membrane protein
Note: Distribution is 50-50.

Keywords

Interaction

Subunit

Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain1-618SecA family profile
Domain87-245Helicase ATP-binding
Domain420-634Helicase C-terminal
Region837-904Disordered
Compositional bias845-875Polar residues

Sequence similarities

Belongs to the SecA family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    904
  • Mass (Da)
    102,846
  • Last updated
    2018-10-10 v1
  • Checksum
    2020FD5555579903
MSFLSKIFGSRNQRIIKRFSKVVEQINQLEPEFEALSDEEVKNKTSEFKSRLEKGETLDNLLPEAFAAVREASKRTLGMRHFDVQLIGGMTLHQGKIGEMRTGEGKTLVATLPVYLNALTGQGVHVITVNDYLAQRDAEWMTPVYNFLGMSVGVILSGQSHEQKQAAYAADITYGTNNEYGFDYLRDNMAFEKEQRVQRELNFAVIDEVDSILIDEARTPLIISGQAEDSSEMYRAINQLIPKLTVQEKESEEGVEDTGDYTIDEKGKQANLTELGQERVEELLRQSGLLPEGQSLYSPASIMLLHHVNAALRAHTLFKKDVDYVVKDNEVVIVDEHTGRTMPGRRWSDGLHQAVEAKEGVNIQNENQTLASITFQNYFRLYNKLSGMTGTADTEATELHMIYGLEVVVIPTNKPMQRQDLPDLIYLSKEEKYAAIIEEIKHLQSKGQPILVGTVSIESSELISKALKKAKVKHQVLNAKFHAKEADIIAQAGRAGSVTIATNMAGRGTDIVLGGNLQSDIDALGENPSEAQIAKVKEEWQKRHDEVLAAGGLAIIGTERHESRRIDNQLRGRAGRQGDPGLSRFYLSLEDDLMRIFASERLGMMMQRLGWEEGEALEHKMVSRAIENAQRKVEQRNFDMRKNLLEYDDVANDQRRVIYEQRNELMESDDIQDTIEDMRYDVVQDVISQYVPPQSIEEMWDIKGLEQRLEQDFAIELPVQKWLDEDDKFAEEEIREKVYNEIQAAYAEKEAALPEPSMMRQLEKQVMLQHLDMHWKEHLGNMDHLRQSIHLRSYAQKNPKQEYKREAFELFSGLLDNLKHDVVTVLSKVKFRLPEEVEAMERPQQDASKMNTQHDSASALPQDQQSDTQRQAETFVREQPKVGRNEPCPCGSGKKFKHCHGKAS

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias845-875Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QICH01000002
EMBL· GenBank· DDBJ
PXF63293.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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