A0A318D3A7 · A0A318D3A7_9GAMM
- ProteinProtein translocase subunit SecA
- GenesecA
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids904 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
Catalytic activity
Cofactor
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cell envelope Sec protein transport complex | |
Cellular Component | cytosol | |
Cellular Component | plasma membrane | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Biological Process | intracellular protein transmembrane transport | |
Biological Process | protein import | |
Biological Process | protein targeting | |
Biological Process | protein transport by the Sec complex |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProtein translocase subunit SecA
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Kangiellales > Kangiellaceae > Kangiella
Accessions
- Primary accessionA0A318D3A7
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Peripheral membrane protein
Membrane ; Peripheral membrane protein
Note: Distribution is 50-50.
Keywords
- Cellular component
Interaction
Subunit
Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-618 | SecA family profile | ||||
Sequence: MSFLSKIFGSRNQRIIKRFSKVVEQINQLEPEFEALSDEEVKNKTSEFKSRLEKGETLDNLLPEAFAAVREASKRTLGMRHFDVQLIGGMTLHQGKIGEMRTGEGKTLVATLPVYLNALTGQGVHVITVNDYLAQRDAEWMTPVYNFLGMSVGVILSGQSHEQKQAAYAADITYGTNNEYGFDYLRDNMAFEKEQRVQRELNFAVIDEVDSILIDEARTPLIISGQAEDSSEMYRAINQLIPKLTVQEKESEEGVEDTGDYTIDEKGKQANLTELGQERVEELLRQSGLLPEGQSLYSPASIMLLHHVNAALRAHTLFKKDVDYVVKDNEVVIVDEHTGRTMPGRRWSDGLHQAVEAKEGVNIQNENQTLASITFQNYFRLYNKLSGMTGTADTEATELHMIYGLEVVVIPTNKPMQRQDLPDLIYLSKEEKYAAIIEEIKHLQSKGQPILVGTVSIESSELISKALKKAKVKHQVLNAKFHAKEADIIAQAGRAGSVTIATNMAGRGTDIVLGGNLQSDIDALGENPSEAQIAKVKEEWQKRHDEVLAAGGLAIIGTERHESRRIDNQLRGRAGRQGDPGLSRFYLSLEDDLMRIFASERLGMMMQRLGWEEGEALE | ||||||
Domain | 87-245 | Helicase ATP-binding | ||||
Sequence: IGGMTLHQGKIGEMRTGEGKTLVATLPVYLNALTGQGVHVITVNDYLAQRDAEWMTPVYNFLGMSVGVILSGQSHEQKQAAYAADITYGTNNEYGFDYLRDNMAFEKEQRVQRELNFAVIDEVDSILIDEARTPLIISGQAEDSSEMYRAINQLIPKLT | ||||||
Domain | 420-634 | Helicase C-terminal | ||||
Sequence: DLPDLIYLSKEEKYAAIIEEIKHLQSKGQPILVGTVSIESSELISKALKKAKVKHQVLNAKFHAKEADIIAQAGRAGSVTIATNMAGRGTDIVLGGNLQSDIDALGENPSEAQIAKVKEEWQKRHDEVLAAGGLAIIGTERHESRRIDNQLRGRAGRQGDPGLSRFYLSLEDDLMRIFASERLGMMMQRLGWEEGEALEHKMVSRAIENAQRKVE | ||||||
Region | 837-904 | Disordered | ||||
Sequence: VEAMERPQQDASKMNTQHDSASALPQDQQSDTQRQAETFVREQPKVGRNEPCPCGSGKKFKHCHGKAS | ||||||
Compositional bias | 845-875 | Polar residues | ||||
Sequence: QDASKMNTQHDSASALPQDQQSDTQRQAETF |
Sequence similarities
Belongs to the SecA family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length904
- Mass (Da)102,846
- Last updated2018-10-10 v1
- Checksum2020FD5555579903
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 845-875 | Polar residues | ||||
Sequence: QDASKMNTQHDSASALPQDQQSDTQRQAETF |